California NanoSystems Institute
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John Miao, Ph.D.

Professor, Physics and Astronomy
Member, California NanoSystems Institute

Ph.D., SUNY at Stony Brook, 1999

Contact Information:
Email Address:
Work Address: UCLA
Department of Physics & Astronomy
Box 951547
3-108 Knudsen
Los Angeles, CA 90095
Home Page:
Home Page:
ARR Papers:
Work Phone Number: (310) 206-2645
Technical Research Interest:

My research interests lie in the interplay of physics, nanoscience and biology. I am particularly interested in developing new physical methods for quantitative imaging of nanoscale materials and biological systems in three dimensions. I have pioneered 3D coherent diffraction microscopy based upon coherent scattering in combination with a method of direct phase recovery called oversampling. I, together with my students, postdocs and collaborators, will continue to improve the spatial resolution of this imaging technique and pursue its applications in nanoscience and biology by using optical lasers, coherent X-rays and electrons. With the prospects of X-ray free electron lasers that are under rapid development worldwide, coherent diffraction microscopy can in principle be used to image non-crystalline specimens at the atomic resolution in three dimensions.

Selected Publications:

M. C. Scott, Chien-Chun Chen, Matthew Mecklenburg, Chun Zhu, Rui Xu, Peter Ercius, Ulrich Dahmen, B. C. Regan & Jianwei Miao, Electron tomography at 2.4-ångström resolution , Nature, 2012, 483, 444-447.
Xu R, Salha S, Raines KS, Jiang H, Chen CC, Takahashi Y, Kohmura Y, Nishino Y, Song C, Ishikawa T, Miao J, Coherent diffraction microscopy at SPring-8: instrumentation, data acquisition and data analysis, J Synchrotron Radiat, 2011, 18 (2), 293-8.
Xiaoqun Zhang; Burger, M.; Bresson, X.; Osher, S., Bregmanized Nonlocal Regularization for Deconvolution and Sparse Reconstruction, SIAM Journal on Imaging Sciences, 2010, 3 (3), 253-76.
Mao Y, Fahimian BP, Osher SJ, Miao J, Development and Optimization of Regularized Tomographic Reconstruction Algorithms Utilizing Equally-Sloped Tomography, IEEE Trans Image Process, 2010, 19 (5), 1259-68.
Fahimian BP, Mao Y, Cloetens P, Miao J, Low-dose x-ray phase-contrast and absorption CT using equally sloped tomography, Phys Med Biol, 2010, 55 (18), 5383-400.
Jiang H, Song C, Chen CC, Xu R, Raines KS, Fahimian BP, Lu CH, Lee TK, Nakashima A, Urano J, Ishikawa T, Tamanoi F, Miao J, Quantitative 3D imaging of whole, unstained cells by using X-ray diffraction microscopy, Proc Natl Acad Sci U S A, 2010, 107 (25), 11234-9.
K. S. Raines, S. Salha, R. L. Sandberg, H. Jiang, J. A. Rodríguez, B. P. Fahimian, H. C. Kapteyn, J. Du and J. Miao, Three-dimensional structure determination from a single view, Nature, 2010, 463 (7278), 214-7.
L. Baghaei, A. Rad, B. Dai, P. Pianetta, R. F. W. Pease and J. Miao, Iterative phase recovery using wavelet domain constraints, J. Vac. Sci. Technol. B , 2009, 7 (6), 3192-3195 .
M. M. Murnane and J. Miao, Optics: Ultrafast X-ray photography, Nature, 2009, 460 (7259), 1088-90 .
Rodríguez JA, Lopez MA, Thayer MC, Zhao Y, Oberholzer M, Chang DD, Kisalu NK, Penichet ML, Helguera G, Bruinsma R, Hill KL, Miao J., Propulsion of African trypanosomes is driven by bihelical waves with alternating chirality separated by kinks, PNAS, 2009, 106 (46), 19322-7.
R. L. Sandberg, D. A. Raymondson, C. La-o-vorakiat, A. Paul, K. S. Raines, J. Miao, M. M. Murnane, H. C. Kapteyn, and W. F. Schlotter , Tabletop soft-x-ray Fourier transform holography with 50 nm resolution, Optics Letters, 2009, 34 (11), 1618-1620 .
Chen, Chien-Chun; Miao, Jianwei; Lee, T. K., Tomographic image alignment in three-dimensional coherent diffraction microscopy, Physical Review B, 2009, 79 (5).
Miao, J. Ishikawa, T. Shen, Q. Earnest, T., Extending X-ray crystallography to allow the imaging of noncrystalline materials, cells, and single protein complexes, Annu Rev Phys Chem, 2008, 59, 387-410.
Richard L. Sandberg, Changyong Song, Przemyslaw W. Wachulak, Daisy A. Raymondson, Ariel Paul, Bagrat Amirbekian, Edwin Lee, Anne E. Sakdinawat, Chan La-O-Vorakiat, Mario C. Marconi, Carmen S. Menoni, Margaret M. Murnane, Jorge J. Rocca, Henry C. Kapteyn, and Jianwei Miao, High numerical aperture tabletop soft x-ray diffraction microscopy with 70-nm resolution, Proc Natl Acad Sci , 2008, 105 (1), 24-27.
Jiang, H. Ramunno-Johnson, D. Song, C. Amirbekian, B. Kohmura, Y. Nishino, Y. Takahashi, Y. Ishikawa, T. Miao, J., Nanoscale imaging of mineral crystals inside biological composite materials using X-ray diffraction microscopy, Phys Rev Lett, 2008, 100 (3), 038103.
Song, C. Bergstrom, R. Ramunno-Johnson, D. Jiang, H. Paterson, D. de Jonge, M. D. McNulty, I. Lee, J. Wang, K. L. Miao, J., Nanoscale imaging of buried structures with elemental specificity using resonant x-ray diffraction microscopy, Phys Rev Lett, 2008, 100 (2), 025504.
Song, C. Jiang, H. Mancuso, A. Amirbekian, B. Peng, L. Sun, R. Shah, S. S. Zhou, Z. H. Ishikawa, T. Miao, J., Quantitative imaging of single, unstained viruses with coherent x rays, Phys Rev Lett, 2008, 101 (15), 158101.
Lee, E., Fahimian, B. P., Iancu, C. V., Suloway, C., Murphy, G. E., Wright, E. R., Castano-Diez, D., Jensen, G. J., Miao, J. , Radiation dose reduction and image enhancement in biological imaging through equally-sloped tomography, J Struct Biol, 2008, 164 (2), 221-7.
Sandberg RL, Paul A, Raymondson DA, Hädrich S, Gaudiosi DM, Holtsnider J, Tobey RI, Cohen O, Murnane MM, Kapteyn HC, Song C, Miao J, Liu Y, Salmassi F, Lensless diffractive imaging using tabletop coherent high-harmonic soft-X-ray beams, Phys Rev Lett, 2007, 99 (9), 098103.
C. Song, D. Ramunno-Johnson, Y. Nishino, Y. Kohmura, T. Ishikawa, C.C. Chen, T.K. Lee and J. Miao, Phase Retrieval from Exactly Oversampled Diffraction Intensity Through Deconvolution, Phys. Rev. B, 2007, 75 (012102).
Miao, J. Chen, C. C. Song, C. Nishino, Y. Kohmura, Y. Ishikawa, T. Ramunno-Johnson, D. Lee, T. K. Risbud, S. H., Three-dimensional GaN-Ga2O3 core shell structure revealed by x-ray diffraction microscopy, Phys Rev Lett, 2006, 97 (21), 215503.
J. Miao, C. Song, Y. Nishino, Y. Kohmura, B. Johnson and T. Ishikawa, 3D Microscopy provides the first deep view, IEEE Tech Digest Tranducers , 2005, 2, 1304-1305.
Y. Kohmura, Y. Nishino, T. Ishikawa and J. Miao, Effect of distorted illumination waves on coherent diffraction microscopy, J. App. Phys. , 2005, 98 (12).
J. Miao, F. Forster and O. Levi, Equally Sloped Tomography with Oversampling Reconstruction, Phys. Rev. B, 2005, 72 (5).
Miao, J. Nishino, Y. Kohmura, Y. Johnson, B. Song, C. Risbud, S. H. Ishikawa, T., Quantitative image reconstruction of GaN quantum dots from oversampled diffraction intensities alone, Phys Rev Lett, 2005, 95 (8), 085503.
I.K. Robinson and J. Miao, Three-Dimensional Coherent X-Ray Diffraction Microscopy, MRS Bulletin, 2004, 29 (03), 177-81 .
Miao, J Chapman, HN Kirz, J Sayre, D Hodgson, KO, Taking X-ray diffraction to the limit: macromolecular structures from femtosecond X-ray pulses and diffraction microscopy of cells with synchrotron radiation, Annu Rev Biophys Biomol Struct, 2004, 33, 157-76.
J. Miao, J. Amonette, Y. Nishino, T. Ishikawa and K. O. Hodgson., Direct Determination of the Absolute Electron Density of Nanostructured and Disordered Materials at Sub-10 nm Resolution, Phys. Rev. B, 2003, 68 (1), 012201.
G.S. Edwards, R.H. Austin, F.E. Carroll, M.L. Copeland, M.E. Couprie, W.E.Gabella, R.F. Haglund, B.A. Hooper, M.S. Hutson, E.D. Jansen, K.M. Joos, D.P. Kiehart, I. Lindau, J. Miao, H.S. Pratisto, J.H. Shen, Y. Tokutake, L. van der Meer and Aihua Xie, Free-electron-laser-based biophysical and biomedical instrumentation, Rev. Sci. Instru, 2003, 74 (7), 3207-45.
Y. Nishino, J. Miao and T. Ishikawa, Image Reconstruction of Nanostructured Non-Periodic Objects Only from Oversampled Hard X-ray Diffraction Intensities, Phys. Rev. B , 2003, 68 (22), 220101.
Miao J, Hodgson KO, Ishikawa T, Larabell CA, LeGros MA, Nishino Y, Imaging whole Escherichia coli bacteria by using single-particle x-ray diffraction, PNAS, 2003, 100 (1), 110-2.
J. Miao, T. Ishikawa, E. H. Anderson and K. O. Hodgson., Phase retrieval of diffraction patterns from noncrystalline samples using the oversampling method, Phys. Rev. B, 2003, 67 (17), 174104.
J. Miao, T. Ohsuna, O. Terasaki, K. O. Hodgson and M. A. O'Keefe, Atomic Resolution Three-Dimensional Electron Diffraction Microscopy, Phys. Rev. Lett, 2002, 89 (15), 155502.
J. Miao, T. Ishikawa, B. Johnson, E. H. Anderson, B. Lai and K. O. Hodgson, High Resolution 3D X-ray Diffraction Microscopy, Phys. Rev. Lett, 2002, 89 (8), 088303.