California NanoSystems Institute
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Kang Ting, D.M.Sc.

Member and Professor and Chair of the Section of Orthodontics, Division of Associated Clinical Specialities, California NanoSystems Institute

D.M.Sc., Harvard School of Dental Medicine, 1994

Contact Information:
Work Email Address:
Office Address: UCLA School Of Dentistry
Section of Orthodontics
10833 Le conte Avenue
Los Angeles, CA 90095
Home Page:
Work Phone Number: (310) 206-6305
Technical Research Interest:

We have a multidisciplinary core team in the area of tissue engineering from Bioengineering, Department of Orthoepdic Surgery, department of Surgery, and the School of Dentistry – Drs. Ben Wu, Chia Soo, and myself. One of the main projects currently funded by the Department of Defense is the „Combining Osteoinductive and Antimicrobial Therapies to Improve Healing of Contaminated/ Infected Segmental Long Bone Defects“. In this project, we investigate the combinatorial effect of nanao silver particles and our novel growth factor in 3D scaffold to regenerate bone. Another ongoing project is supported by the UC Discovery to examine effect of a novel growth factor we identified in cartilage regeneration utilizing nano-size hydroxyapatite coated scaffold. We also in the process of trying to utilize the EM in CNSI to study the structure of this novel pgrowth factor in order to predict the functional domains.

Selected Publications:

Aaron W. James, Janette N. Zara, Xinli Zhang, Asal Askarinam, Raghav Goyal, Michael Chiang, Wei Yuan, Le Chang, Mirko Corselli, Jia Shen, Shen Pang, David Stoker, Ben Wu, Kang Ting, Bruno Péault and Chia Soo, Perivascular Stem Cells: A Prospectively Purified Mesenchymal Stem Cell Population for Bone Tissue Engineering, Stem Cells Translational Medicine, 2012, DOI: 10.5966/sctm.2012-0002.
Zheng Z, Nguyen C, Zhang X, Khorasani H, Wang JZ, Zara JN, Chu F, Yin W, Pang S, Le A, Ting K, Soo C, Delayed wound closure in fibromodulin-deficient mice is associated with increased TGF-?3 signaling, J Invest Dermatol, 2011, 131 (3), 769-78.
Zara JN, Siu RK, Zhang X, Shen J, Ngo R, Lee M, Li W, Chiang M, Chung J, Kwak J, Wu BM, Ting K, Soo C, High Doses of Bone Morphogenetic Protein 2 Induce Structurally Abnormal Bone and Inflammation In Vivo, Tissue Eng Part A, 2011, Epub ahead of print.
Siu RK, Lu SS, Li W, Whang J, McNeill G, Zhang X, Wu BM, Turner AS, Seim HB, Hoang P, Wang JC, Gertzman AA, Ting K, Soo C, Nell-1 Protein Promotes Bone Formation in a Sheep Spinal Fusion Model, Tissue Eng Part A, 2011, 17 (7-8), 1123-35.
Li W, Zara JN, Siu RK, Lee M, Aghaloo T, Zhang X, Wu BM, Gertzman AA, Ting K, Soo C, Nell-1 enhances bone regeneration in a rat critical-sized femoral segmental defect model, Plast Reconstr Surg, 2011, 127 (2), 580-7.
Zhang X, Ting K, Bessette CM, Culiat CT, Sung SJ, Lee H, Chen F, Shen J, Wang JJ, Kuroda S, Soo C, Nell-1, a key functional mediator of Runx2, partially rescues calvarial defects in Runx2(+/-) mice, J Bone Miner Res, 2011, 26 (4), 777-91.
Li W, Lee M, Whang J, Siu RK, Zhang X, Liu C, Wu BM, Wang JC, Ting K, Soo C, Delivery of lyophilized Nell-1 in a rat spinal fusion model, Tissue Eng Part A, 2010, 16 (9), 2861-70.
Lee M, Siu RK, Ting K, Wu BM, Effect of Nell-1 Delivery on Chondrocyte Proliferation and Cartilaginous Extracellular Matrix Deposition, Tissue Eng Part A, 2010, 16 (5), 1791-800.
Xianyan Yang, Xin Gao, Yilai Gan, Changyou Gao, Xinli Zhang, Kang Ting, Benjamin M. Wu and Zhongru Gou, Facile Synthesis of Octacalcium Phosphate Nanobelts: Growth Mechanism and Surface Adsorption Properties, J. Phys. Chem. C, 2010, 114 (14), 6265–6271.
Aghaloo T, Cowan CM, Zhang X, Freymiller E, Soo C, Wu B, Ting K, Zhang Z, The effect of NELL1 and bone morphogenetic protein-2 on calvarial bone regeneration, J Oral Maxillofac Surg, 2010, 68 (2), 300-8.
Zheng Z, Yin W, Zara JN, Li W, Kwak J, Mamidi R, Lee M, Siu RK, Ngo R, Wang J, Carpenter D, Zhang X, Wu B, Ting K, Soo C, The use of BMP-2 coupled - Nanosilver-PLGA composite grafts to induce bone repair in grossly infected segmental defects, Biomaterials, 2010, 31 (35), 9293-300.
Lee M, Li W, Siu RK, Whang J, Zhang X, Soo C, Ting K, Wu BM, Biomimetic apatite-coated alginate/chitosan microparticles as osteogenic protein carriers, Biomaterials, 2009, 30 (30), 6094-101.
Lee H, Ting K, Nelson M, Sun N, Sung SJ, Maxillary expansion in customized finite element method models, Am J Orthod Dentofacial Orthop, 2009, 136 (3), 367-74.
Chow, A. Lee, H. F. Kawamoto, H. Vastardis, H. Ting, K., Cephalometric evaluation of the craniofacial complex in patients treated with an intraoral distraction osteogenesis device: A long-term study, American Journal of Orthodontics and Dentofacial Orthopedics, 2008, 134 (6), 724-731.
Warren SM, Walder B, Dec W, Longaker MT, Ting K, Confocal laser scanning microscopic analysis of collagen scaffolding patterns in cranial sutures, J Craniofac Surg, 2008, 19 (1), 198-203.
Bokui, N. Otani, T. Igarashi, K. Kaku, J. Oda, M. Nagaoka, T. Seno, M. Taternatsu, K. Okajima, T. Matsuzaki, T. Ting, K. Tanizawa, K. Kuroda, S., Involvement of MAPK signaling molecules and Runx2 in the NELL1-induced osteoblastic differentiation, Febs Letters, 2008, 582 (2), 365-371.
Aghaloo, T. Jiang, X. Q. Soo, C. Zhang, Z. Y. Zhang, X. L. Hu, J. Z. Pan, H. Y. Hsu, T. Wu, B. Ting, K. Zhang, X. L., A study of the role of Nell-1 gene modified goat bone marrow stromal cells in promoting new bone formation, Molecular Therapy, 2007, 15 (10), 1872-1880.
Truong, T. Zhang, X. L. Pathmanathan, D. Soo, C. Ting, K., Craniosynostosis-associated gene Nell-1 is regulated by Runx2, Journal of Bone and Mineral Research, 2007, 22 (1), 7-18.
Cowan, C. M. Aghaloo, T. Chou, Y. F. Walder, B. Zhang, X. L. Soo, C. Ting, K. Wu, B., MicroCT evaluation of three-dimensional mineralization in response to BMP-2 doses in vitro and in critical sized rat calvarial defects, Tissue Engineering, 2007, 13 (3), 501-512.
Cowan, C. M. Jiang, X. Q. Hsu, T. Soo, C. Zhang, B. J. Wang, J. Z. Kuroda, S. Wu, B. Zhang, Z. Y. Zhang, X. L. Ting, K., Synergistic effects of Nell-1 and BMP-2 on the osteogenic differentiation of myoblasts, Journal of Bone and Mineral Research, 2007, 22 (6), 918-930.
Lu SS, Zhang X, Soo, S, Hsu T, Wu B. Tsou P, Ting K, Wang JC, The Osteoinductive Properties of Nell-1 in a Rodent Spinal Fusion Model, Spine, 2007, 7 (1), 50-60.
Cowan, C. M. Cheng, S. Ting, K. Soo, C. Walder, B. Wu, B. Kuroda, S. Zhang, X. L., Nell-1 induced bone formation within the distracted intermaxillary suture, Bone, 2006, 38 (1), 48-58.
Zhang, X. L. Cowan, C. M. Jiang, X. Q. Soo, C. Miao, S. Carpenter, D. Wu, B. Kuroda, S. Ting, K., Nell-1 induces acrania-like cranioskeletal deformities during mouse embryonic development, Laboratory Investigation, 2006, 86 (7), 633-644.
Aghaloo, T. Cowan, C. M. Chou, Y. F. Zhang, X. L. Lee, H. F. Miao, S. Hong, N. Kuroda, S. Wu, B. Ting, K. Soo, C., Nell-1-induced bone regeneration in calvarial defects, American Journal of Pathology, 2006, 169 (3), 903-915.
Patel, P. N. Zhang, X. L. Ting, K. Chang, X. L. Soo, C., Fibromodulin deficient adult mice exhibit increased scar formation and altered transforming growth factor-beta1 expression, Journal of the American College of Surgeons, 2005, 201 (3), S60-S60.
Law, C. S. Warren, S. M. Mehrara, B. J. Ting, K., Gene expression profiling in the rat cranial suture, Journal of Craniofacial Surgery, 2005, 16 (3), 378-388.
Colwell, A. S. Beanes, S. R. Soo, C. Dang, C. Ting, K. Longaker, M. T. Atkinson, J. B. Lorenz, H. P., Increased angiogenesis and expression of vascular endothelial growth factor during scarless repair, Plastic and Reconstructive Surgery, 2005, 115 (1), 204-212.
Aghaloo, T. L. Jiang, X. Q. Zhang, X. L. Zhang, Z. Y. Soo, C. Wu, B. Ting, K., Nell-1 induces bone marrow stromal cell differentiation and mineralization in vitro and bone formation in vivo, Journal of the American College of Surgeons, 2005, 201 (3), S45-S45.
Cowan, C. Aghaloo, T. Chou, Y. F. Zhang, X. L. Lee, H. Wu, B. Ting, K. Soo, C., Nell-1 induces osteogenic differentiation and bone formation within calvarial defects, Journal of the American College of Surgeons, 2005, 201 (3), S61-S61.
Jiang X, Wu B, X zhang, Ting K, X Zhang, Nell-1,a Cbfa-1 downstream mediator, in inducing bone formation, J. Dent. Res, 2005.
Neil DS, Morris J, Law CS, Zhang X, Lyons KM, and Ting K, Effect of Bone Inducing Proteins on the Expanded Midpalatal Suture, J. Dent. Res, 2004, 83, 1305.
Trahar M, Sheffeld R, Yang JH, Kawamoto H, Landsberger S, and Ting K, Cephalometric Evaluation of the Craniofacial Complex, Am. J. Ortho, 2003, 124 (6), 639-650.
Dang, C. M. Beanes, S. R. Soo, C. Ting, K. Benhaim, P. Hedrick, M. H. Lorenz, H. P., Decreased expression of fibroblast and keratinocyte growth factor isoforms and receptors during scarless repair, Plastic and Reconstructive Surgery, 2003, 111 (6), 1969-1979.
Dang, C. Ting, K. Soo, C. Longaker, M. T. Lorenz, H. P., Fetal wound healing - Current perspectives, Clinics in Plastic Surgery, 2003, 30 (1), 13-23.
Soo, C. Beanes, S. R. Hu, F. Y. Zhang, X. L. Dang, C. Chang, G. Wang, Y. Nishimura, I. Freymiller, E. Longaker, M. T. Lorenz, H. P. Ting, K., Ontogenetic transition in fetal wound transforming growth factor-beta regulation correlates with collagen organization, American Journal of Pathology, 2003, 163 (6), 2459-2476.
Zhang, X. L. Carpenter, D. Bokui, N. Soo, C. Miao, S. Truong, T. Wu, B. Chen, I. Vastardis, H. Tanizawa, K. Kuroda, S. Ting, K., Overexpression of Nell-1, a craniosynostosis-associated gene, induces apoptosis in osteoblasts during craniofacial development, Journal of Bone and Mineral Research, 2003, 18 (12), 2126-2134.
Dang, C. M. Beanes, S. R. Lee, H. Zhang, X. L. Soo, C. Ting, K., Scarless fetal wounds are associated with an increased matrix metalloproteinase-to-tissue-derived inhibitor of metalloproteinase ratio, Plastic and Reconstructive Surgery, 2003, 111 (7), 2273-2285.
Beanes, S. R. Hu, F. Y. Soo, C. Dang, C. M. H. Urata, M. Ting, K. Atkinson, J. B. Benhaim, P. Hedrick, M. H. Lorenz, H. P., Confocal microscopic analysis of scarless repair in the fetal rat: Defining the transition, Plastic and Reconstructive Surgery, 2002, 109 (1), 160-170.
Zhang, X. L. Kuroda, S. Carpenter, D. Nishimura, I. Soo, C. Moats, R. Iida, K. Wisner, E. Hu, F. Y. Miao, S. Beanes, S. Dang, C. Vastardis, H. Longaker, M. Tanizawa, K. Kanayama, N. Saito, N. Ting, K., Craniosynostosis in transgenic mice overexpressing Nell-1, Journal of Clinical Investigation, 2002, 110 (6), 861-870.
Lee, H. F. Dang, C. Zhang, X. Beanes, S. Ting, K. Soo, C., Matrix metalloproteinases and thier tissue-derived inhibitors in fetal wound healing, Journal of Dental Research, 2002, 81, A493-A493.
Zhang X, Miao S, Soo C, Carpenter D, Dang C, Longaker MT, and Ting K, Nell-1, Modulated by Cbfa1 and Msx2, Induces Calvarial Bone Overgrowth, J. Am. College Surgeon, 2002, 195 (3), S44-S53.
Soo, C. Sayah, D. N. Zhang, X. L. Beanes, S. R. Nishimura, I. Dang, C. Freymiller, E. Ting, K., The identification of novel wound-healing genes through differential display, Plastic and Reconstructive Surgery, 2002, 110 (3), 787-797.