California NanoSystems Institute
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Jacob Schmidt, Ph.D.

Associate Professor, Bioengineering
Member, California NanoSystems Institute, Neuroengineering Training Program

Ph.D., University of Minnesota, 1999

Professional Societies:
Biophysical Society
Materials Research Society
American Physical Society

Contact Information:
Work Email Address:
Mailing Address: UCLA
Box 951500
Los Angeles, CA
Mailing Address: Mail Code: 160010
Los Angeles, CA 90095
Group Home Page Redirect:
Fax Number: (310) 204-5956
Work Phone Number: (310) 267-4985 Bioengineering Main Line
(310) 825-4451 Office
Research Interests:

Nanobiotechnology; Single molecule sensing using membrane proteins; Biomimetic membranes; microfluidics; manipulation and creation of biologically-functionalized devices

Technical Research Interest:

Professor Schmidt and his group have strong interests in single molecule biophysics and bioengineering, with a focus on biological membranes and membrane proteins: 1) creation of long-lived and robust biomimetic membranes; 2) singlemolecule transport measurements of membrane proteins; 3) construction of devices and apparatus for the manipulation and study of biomimetic membranes and membrane proteins. The techniques used to pursue these interests are highly multi-disciplinary, drawing on methods of genetic cloning and manipulation, biochemistry, micromachining, low-noise electronics, and microfluidics. The group aims to advance the science and technology of membrane proteins through the development of tools and techniques enabling other researchers to perform experiments previously impossible due to limitations in technology or expertise. The group also maintains a strong interest in technology development enabling more efficient drug discovery targeted toward membrane transport and channel proteins.

Selected Publications:

J L Poulos, S A Portonovo, H Bang and J J Schmidt, Automatable Lipid Bilayer Formation and ion Channel Measurement Using Sessile Droplets, Journal of Physics: Condensed Matter, 2010, 22 (45), 454105.
Poulos JL, Jeon TJ, Schmidt JJ, Automatable production of shippable bilayer chips by pin tool deposition for an ion channel measurement platform, Biotechnol J, 2010, 5 (5), 511-4.
Thapliyal T, Poulos JL, Schmidt JJ, Automated lipid bilayer and ion channel measurement platform, Biosens Bioelectron, 2010, 26 (5), 2651-4.
Tan, R., McClure, T., Lin, C.K., Jea, D., Dabiri, F., Massey, T., Sarrafzadeh, M., Srivastava, M., Montemagno, C.D., Schulam, P., Schmidt, J., Development of a fully implantable wireless pressure monitoring system , Biomedical Microdevices, 2009, 11 (1), 259-264.
Tan R, McClure T, Schulam P, Schmidt J., Development of a minimally invasive implantable wireless vital signs sensor platform, Stud Health Technol Inform. , 2009, 142, 380-5.
Robert F. Purnell and Jacob J. Schmidt, Discrimination of Single Base Substitutions in a DNA Strand Immobilized in a Biological Nanopore, ACS Nano, 2009, 3 (9), 2533ā€“2538.
Jason L. Poulos, Wyatt C. Nelson, Tae-Joon Jeon, Chang-Jin ā€œCJā€ Kim, and Jacob J. Schmidt, Electrowetting on dielectric-based microfluidics for integrated lipid bilayer formation and measurement, Appl. Phys. Lett, 2009, 95, 013706.
Yi, J., Schmidt, J., Chien, A., Montemagno, C., Engineering an artificial amoeba propelled by nanoparticle-triggered actin polymerization, Nanotechnology , 2009, 20.
Poulos, J. L. Jeon, T. J. Damoiseaux, R. Gillespie, E. J. Bradley, K. A. Schmidt, J. J., Ion channel and toxin measurement using a high throughput lipid membrane platform, Biosens Bioelectron, 2009, 24 (6), 1806-10.
Poulos, J.L., Bang, H., Jeon, T.J., Schmidt, J.J. , Automatable lipid bilayer formation for ion channel studies, Proc. SPIE, 2008, 7035.
Jeon TJ, Malmstadt N, Poulos JL, Schmidt JJ, Black lipid membranes stabilized through substrate conjugation to a hydrogel, Biointerphases, 2008, 3 (2), FA96.
Jeon, T. J. Poulos, J. L. Schmidt, J. J., Long-term storable and shippable lipid bilayer membrane platform, Lab Chip, 2008, 8 (10), 1742-4.
Purnell, R. F. Mehta, K. K. Schmidt, J. J., Nucleotide identification and orientation discrimination of DNA homopolymers immobilized in a protein nanopore, Nano Lett, 2008, 8 (9), 3029-34.
Jeon, T.J., Malmstadt, N., Schmidt, J.J. , Creating conjugated hydrogel encapsulated membranes, Materials Research Society Symposium Proceedings, 2007, 950.
Lin, C.K., Jea, D., Dabiri, F., Massey, T., Tan, R., Sarrafzadeh, M., Srivastava, M.B., Schulam, P.G., Schmidt, J.J., Montemagno, C., The Development of an In-vivo Active Pressure Monitoring System, IFBME Proceedings, 2007, 13, 105-110.
Denise Wong, Tae-Joon Jeon and Jacob Schmidt, "Single molecule measurements of channel proteins incorporated into biomimetic polymer membranes", Nanotechnology, 2006, 17, 3710-3717.
Noah Malmstadt, Michael A. Nash, Robert F. Purnell, and Jacob J. Schmidt, Automated Formation of Lipid-Bilayer Membranes in a Microfluidic Device, Nano Lett, 2006, 6 (9), 1961-1965.
Branden Brough, Brian H. Northrop, Jacob J. Schmidt, Hsian-Rong Tseng, Kendall N. Houk, J. Fraser Stoddart, and Chih-Ming Ho, Evaluation of Synthetic Linear Motor-Molecule Actuation Energetics, PNAS, 2006, 103 (23), 8583-8588.
Tae-Joon Jeon, Noah Malmstadt, and Jacob J. Schmidt, Hydrogel-Encapsulated Lipid Membranes, JACS, 2006, 128 (1), 42-43.
Jacob J. Schmidt., "Stochastic Sensors", Journal of Materials Chemistry, 2005, 15, 831-840.
J. Xi, J.J. Schmidt, C.D. Montemagno, Self-assembled microdevices driven by muscle, Nature Materials , 2005, 4 (2), 180.
Sanguk Kim, Tae-Joon Jeon, Amit Oberai, Duan Yang, Jacob J. Schmidt, and James U. Bowie, Transmembrane glycine zippers: Physiological and pathological roles in membrane proteins, PNAS, 2005, 102 (40), 14278.
Jacob J. Schmidt and Carlo D. Montemagno., "Bionanomechanical Systems", Annual Review of Materials Research, 2004, 34, 315-337.
D. Ho, B. Chu, J.J. Schmidt, E.K. Brooks, C.D. Montemagno, Hybrid Protein-Polymer Biomimetic Membranes, IEEE Transactions on Nanotechnology, 2004, 3 (2), 1.
M. J. Casavant, D. A. Walters, J. J. Schmidt, and R. E. Smalley, Neat macroscopic membranes of aligned carbon nanotubes, J. Appl. Phys. , 2003, 93 (5), 2153.
Haiqing Liu, Jacob Schmidt, George Bachand, Shahir Rizk, Loren Looger, Homme Hellinga, and Carlo Montemagno, Control of a biomolecular motor-powered nanodevice with an engineered chemical switch, Nature Materials, 2002, 1, 173.
Jacob Schmidt, Xingqun Jiang, and Carlo Montemagno, Force Tolerances of Hybrid Nanodevices, NanoLetters, 2002, 2 (11), 1229-1233.
El-Arabi Ahmad M, Salazar Carl S, Schmidt Jacob J, Ion channel drug potency assay with an artificial bilayer chip, Lab on a chip, 2012.