California NanoSystems Institute
Text Size: A A A A

Tatiana Segura, Ph.D.

Associate Professor, Chemical and Biomolecular Engineering
Member, California NanoSystems Institute, Materials Creation Training Program IGERT, Tumor Immunology Program at the Jonsson Comprehensive Cancer Center (JCCC)

Ph.D., Northwestern University, 2004
B.S., UC Berkeley, 1999

Honors and Awards:
NRSA Postdoctoral Fellow
Northwestern University, Dissertation Henderson Fellowship
National Institutes of Health, National Institutes of Health Predoctoral Biotechnology Training Grant

Professional Societies:
Society for Biomaterials
American Institute of Chemical Engineers
American Chemical Society

Contact Information:
Email Address:
Work Email Address:
Mailing Address: UCLA
Department of Chemical and Biomolecular Engineering
420 Westwood Blvd
Boelter Hall 5532-C
Los Angeles, CA 90095
Home Page:
Work Phone Number: (310) 206 3980
Research Interests:

The Segura laboratory research focuses on nucleic acid delivery strategies for tissue regeneration and adult stem cell differentiation applications. Non-viral gene delivery, which can be used to deliver any gene in the genome, is a safe, yet robust way to induce up-regulation of desired angiogenic signals; however, inefficient gene transfer has hindered the wide applicability of this approach. The Segura laboratory investigates novel approaches for gene delivery, which exploit the tissue-engineering matrix as a key player in the process of gene transfer. They use the principles of engineering, chemistry, and life sciences to develop biomaterials that can be used simultaneously as scaffolds to guide tissue regeneration, stem cell differentiation and guide efficient and controlled gene transfer.

Additional Information:

Dr. Tatiana Segura is a native of Bogotá, Colombia. She received her diploma from the Escuela Pedagogia Experimental (EPE), an experimental educational school in Bogotá, Colombia. Dr. Segura began her scientific training at the University of California, Berkeley where she received a BS in Bioengineering and a minor in Chemical Engineering. She later obtained her Ph.D in Chemical Engineering at Northwestern University. Dr. Segura pursued postdoctoral research training at the Swiss Federal Institute of Technology in Lausanne, Switzerland. She joined the Chemical and Biomolecular Engineering Department at UCLA in July 2006. Dr. Segura has received the NSF CAREER Award, "Hydrogels for Matrix-Tethered Gene Delivery."

Selected Publications:

Ming Yan, Juanjuan Du, Zhen Gu, Min Liang, Yufang Hu, Wenjun Zhang, Saul Priceman, Lily Wu, Z. Hong Zhou, Zheng Liu, Tatiana Segura, Yi Tang, Yunfeng Lu, A novel intracellular protein delivery platform based on single-protein nanocapsules, Nature Nanotechnology, 2010, 5, 48-53.
Chen TT, Luque A, Lee S, Anderson SM, Segura T, Iruela-Arispe ML, Anchorage of VEGF to the extracellular matrix conveys differential signaling responses to endothelial cells, J Cell Biol, 2010, 188 (4), 595-609.
Dhaliwal A, Maldonado M, Han Z, Segura T, Differential uptake of DNA-poly(ethylenimine) polyplexes in cells cultured on collagen and fibronectin surfaces, Acta Biomater, 2010, 6 (9), 3436-47.
Lei Y, Ng QK, Segura T, Two and three-dimensional gene transfer from enzymatically degradable hydrogel scaffolds, Microsc Res Tech, 2010, 73 (9), 910-7.
Tokatlian T, Segura T, siRNA applications in nanomedicine, Wiley Interdiscip Rev Nanomed Nanobiotechnol, 2010, 2 (3), 305-15.
Lei Y, Segura T., DNA delivery from matrix metalloproteinase degradable poly(ethylene glycol) hydrogels to mouse cloned mesenchymal stem cells, Biomaterials, 2009, 30 (2), 254-65.
Ng, Q. K. T. Sutton, M. K. Soonsawad, P. Xing, L. Cheng, H. Segura, T., Engineering Clustered Ligand Binding Into Nonviral Vectors: alpha(v)beta(3) Targeting as an Example, Molecular Therapy, 2009, 17 (5), 828-836.
Anderson SM, Chen TT, Iruela-Arispe ML, Segura T, The phosphorylation of vascular endothelial growth factor receptor-2 (VEGFR-2) by engineered surfaces with electrostatically or covalently immobilized VEGF, Biomaterials, 2009, 30 (27), 4618-28.
Adelow, C. Segura, T. Hubbell, J. A. Frey, P., Bioactive poly(ethylene glycol) hydrogels for modulation of the smooth muscle cell phenotype, Tissue Engineering Part A, 2008, 14 (5), 811-811.
Adeloew, C. Segura, T. Hubbell, J. A. Frey, P., The effect of enzymatically degradable poly(ethylene glycol) hydrogels on smooth muscle cell phenotype, Biomaterials, 2008, 29 (3), 314-326.
Segura, T. Schmokel, H. Hubbell, J. A., RNA interference targeting hypoxia inducible factor 1 alpha reduces post-operative adhesions in rats, Journal of Surgical Research, 2007, 141 (2), 162-170.
Segura, T. Hubbell, J. A., Synthesis and in vitro characterization of an ABC triblock copolymer for siRNA delivery, Bioconjugate Chemistry, 2007, 18 (3), 736-745.
T Segura, BC Anderson, PH Chung, RE Webber, KR Shull, and LD Shea, Crosslinked Hyaluronic Acid Hydrogels: A Strategy to Functionalize and Pattern, Biomaterials, 2005, 26 (4), 359-371.
Tatiana Segura, Peter H. Chung and Lonnie D. Shea, DNA Delivery from Hyaluronic Acid-Collagen Hydrogels: a solid phase delivery approach, Biomaterials, 2005, 26 (13), 1575-84.
Bengali, Z, Pannier, AK, Segura, T, Anderson, BC, Jang, JH, Mustoe, TA and Shea, LD, Gene delivery through cell culture substrate adsorbed DNA Complexes, Biotechnology and Bioengineering, 2005, 90 (3), 290-302.
T Segura, MJ Volk, LD Shea, Substrate-Mediated DNA Delivery: Role of the Cationic Polymer Structure and Extent of Modification, Journal of Controlled Release, 2003, 93 (1), 69-84.
T Segura, and LD Shea, Surface-Tethered DNA Complexes for Enhanced Gene Delivery, Bioconjugate Chemistry, 2002, 13 (3), 621-9.