California NanoSystems Institute
CNSI
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R. Michael van Dam, Ph.D.

   
Associate Professor, Crump Institute for Molecular Imaging, Molecular & Medical Pharmacology
Member, California NanoSystems Institute, Molecular Pharmacology GPB Home Area, Physics & Biology in Medicine GPB Home Area

Education:
Degrees:
Ph.D., California Institute of Technology
M.S., University of Toronto
B.S., Queen's University

Contact Information:
Work Email Address: mvandam@mednet.ucla.edu
Laboratory Address: Lab
4310 CNSI, 570 Westwood Plaza, Building 114
Los Angeles, CA 90095
UNITED STATES
Office Address: Office
4323 CNSI, 570 Westwood Plaza, Building 114
Los Angeles, CA 90095
UNITED STATES
Group Home Page Redirect: http://vandamlab.org
Lab Number: 310-794-1731 Lab
Office Phone Number: 310-206-6507 Office
Research Interests:

Developing technologies to make molecular imaging more accessible
My laboratory is interested in making cutting edge molecular imaging methods (e.g. positron emission tomography, PET) more accessible. We are developing improved ways to produce diverse PET tracers at lower cost for research and clinical use. Our research involves developing new automated and miniaturized technologies to streamline all phases of the tracer production process. We also produce tracers for various research groups for imaging of various biological processes (including metabolism, gene expression, cell proliferation, etc.), and we produce labeled peptides and proteins to image receptors and structural proteins with high specificity. We collaborate with several groups on the development of novel PET tracers and on the development of new chemistry approaches for simplified tracer production.


Technical Research Interest:

Microfluidics and automation in molecular imaging (e.g., production of radiopharmaceuticals, and molecular imaging assays)
My group is interested in novel microfluidic technologies and automated systems for solving problems in cancer research and molecular imaging. Recent and current technology development projects include: (i) development a flexible radiosynthesizer and software for automated production of diverse radiolabeled tracers for positron emission tomography (PET); (ii) development of microscale approaches for each step of the PET tracer production process, with the goal of enabling benchtop production of tracers on demand; (iii) microchip-based synthesis platform to leverage the advantages of microliter-scale synthesis of molecular imaging tracers; (iv) miniaturized methods for quality control testing of PET tracers; (v) high-throughput platforms for PET tracer discovery and optimization; and (vi) technology platforms for in vitro evaluation of molecular imaging tracers. Because we are developing technology tools that we hope can ultimately be used by others and automated, we emphasize issues such as robustness, reliability, manufacturability, and user interface in our approaches. In addition to technology development, we produce known PET tracers for imaging studies by various on-campus and external groups, we assist in the development of novel PET tracers, and we assist in the development of novel chemistry approaches for radiolabeling.



Selected Publications:

Sun Jing, Masterman-Smith Michael D, Graham Nicholas A, Jiao Jing, Mottahedeh Jack, Laks Dan R, Ohashi Minori, DeJesus Jason, Kamei Ken-ichiro, Lee Ki-Bum, Wang Hao, Yu Zeta T F, Lu Yi-Tsung, Hou Shuang, Li Keyu, Liu Max, Zhang Nangang, Wang Shutao, Angenieux Brigitte, Panosyan Eduard, Samuels Eric R, Park Jun, Williams Dirk, Konkankit Vera, Nathanson David, van Dam R Michael, Phelps Michael E, Wu Hong, Liau Linda M, Mischel Paul S, Lazareff Jorge A, Kornblum Harley I, Yong William H, Graeber Thomas G, Tseng Hsian-Rong, A microfluidic platform for systems pathology: multiparameter single-cell signaling measurements of clinical brain tumor specimens, Cancer research, 2010, 70 (15), 6128-38.
Elizarov Arkadij M, van Dam R Michael, Shin Young Shik, Kolb Hartmuth C, Padgett Henry C, Stout David, Shu Jenny, Huang Jiang, Daridon Antoine, Heath James R, Design and optimization of coin-shaped microreactor chips for PET radiopharmaceutical synthesis, Journal of nuclear medicine, 2010, 51 (2), 282-7.
Elizarov Arkadij M, Meinhart Carl, Miraghaie Reza, van Dam R Michael, Huang Jiang, Daridon Antoine, Heath James R, Kolb Hartmuth C, Flow optimization study of a batch microfluidics PET tracer synthesizing device, Biomedical microdevices, 2010, 13 (1), 231-42.
Liu Kan, Chen Yi-Chun, Tseng Hsian-Rong, Shen Clifton Kwang-Fu, van Dam R Michael, Microfluidic device for robust generation of two-component liquid-in-air slugs with individually controlled composition, Microfluidics and nanofluidics, 2010, 9 (4-5), 933-943.
Cho Jennifer S, Taschereau Richard, Olma Sebastian, Liu Kan, Chen Yi-Chun, Shen Clifton K-F, van Dam R Michael, Chatziioannou Arion F, Cerenkov radiation imaging as a method for quantitative measurements of beta particles in a microfluidic chip, Phys Med Biol, 2009, 54 (22), 6757-71.
J. S. Cho, A. Douraghy, S. Olma, K. Liu, Y. C. Chen, C. K. Shen, R. W. Silverman, R. M. van Dam, A. F. Chatziioannou, Čerenkov Radiation Imaging as a Method for Quantitative Measurements of Beta Particles in a Microfluidic Chip, Proceedings of IEEE Nuclear Science Symposium and Medical Imaging Conference, 2008, 4510-4515.
van Dam, R.M., Elizarov, A.M., Ball, E., Shen, C.K-F , Kolb, H., Rolland, J., Diener, L., Williams D., Edgecombe, B., Stephen, T., Heath, J.R., Automated microfluidic chip and system for the synthesis of radiopharmaceuticals on human-dose scales, Proc. Nanotech 2007, 2007, 3, 300-303.
Maltezos George, Garcia Erika, Hanrahan Grady, Gomez Frank A, Vyawahare Saurabh, Vyawhare Saurabh, van Dam R Michael, Chen Yan, Scherer Axel, Design and fabrication of chemically robust three-dimensional microfluidic valves, Lab on a chip, 2007, 7 (9), 1209-11.
Elizarov, A.M., Kolb, H.C., van Dam, R.M., Heath, J.R., Padgett, H.C., Huang, J., Daridon, A. , Coin-shaped reactor in microfluidic devices used for radiopharmaceutical synthesis, Proc. Nanotech 2006, 2006, 2, 542-545.
Elizarov, A.M., van Dam, R.M., Heath, J.R., Kolb, H.C., Huang, J., Daridon, A. , Microfluidic device with coin-shaped reactor for radiopharmaceutical synthesis, Proc. ACS 2006, 2006.
Rolland, J.P., van Dam, R.M., Hagberg, E.C., Carter, K.R., Quake, S.R., DeSimone, J., Functional perfluoropolyethers as novel materials for microfluidics and soft lithography, Polymer Preprints, 2004, 45 (2), 106-107.
Rolland, J.P., Zhou, Z., Kelly, J.Y., Denison, G.M., van Dam, R.M., Hagberg, E.C., Carter, K.R., Quake, S.R., DeSimone, J.M, Liquid precursors for applications in microfluidics, soft lithography, and fuel cells, PMSE Preprints, 2004, 91, 254-255.
Rolland Jason P, Van Dam R Michael, Schorzman Derek A, Quake Stephen R, DeSimone Joseph M, Solvent-resistant photocurable liquid fluoropolymers for microfluidic device fabrication [corrected], Journal of the American Chemical Society, 2004, 126 (8), 2322-3.
Reese Matthew O, van Dam R Michael, Scherer Axel, Quake Stephen R, Microfabricated fountain pens for high-density DNA arrays, Genome research, 2003, 13 (10), 2348-52.
van Dam R Michael, Quake Stephen R, Gene expression analysis with universal n-mer arrays, Genome research, 2002, 12 (1), 145-52.
Sadeghi Saman, Ding Huijiang, Shah Gaurav J, Chen Supin, Keng Pei Yuin, Kim Chang-Jin Cj, van Dam R Michael, On chip droplet characterization: A practical, high-sensitivity measurement of droplet impedance in digital microfluidics, Analytical chemistry, 2012.
Keng Pei Yuin, Chen Supin, Ding Huijiang, Sadeghi Saman, Shah Gaurav J, Dooraghi Alex, Phelps Michael E, Satyamurthy Nagichettiar, Chatziioannou Arion F, Kim Chang-Jin CJ, van Dam R Michael, Micro-chemical synthesis of molecular probes on an electronic microfluidic device, Proceedings of the National Academy of Sciences of the United States of America, 2011.
Ying-Wei Yang, Jens Hentschel, Yi-Chun Chen, Mark Lazari, Hanxiang Zeng, R. Michael van Dam, Zhibin Guan, “Clicked” fluoropolymer elastomers as robust materials for potential microfluidic device applications, Journal of Materials Chemistry, 2011, 22, 1100-1106.
Pei Yuin Keng, Melissa Esterby, R. Michael van Dam, Emerging Technologies for Decentalized Production of PET Tracers, Positron Emission Tomography - Current Clinical and Research Aspects, 2012, 153-182.
Ding Huijiang, Sadeghi Saman, Shah Gaurav J, Chen Supin, Keng Pei Yuin, Kim Chang-Jin C J, van Dam R Michael, Accurate dispensing of volatile reagents on demand for chemical reactions in EWOD chips, Lab on a chip, 2012, 12 (18), 3331-40.
Herman Henry, Flores Graciela, Quinn Kevin, Eddings Mark, Olma Sebastian, Moore Melissa D, Ding Huijiang, Bobinski Krzysztof P, Wang Mingwei, Williams Dirk, Wiliams Darin, Shen Clifton Kwang-Fu, Phelps Michael E, van Dam R Michael, Plug-and-play modules for flexible radiosynthesis, Applied radiation and isotopes, 2013, 78, 113-24.
Shah Gaurav J, Ding Huijiang, Sadeghi Saman, Chen Supin, Kim Chang-Jin Cj, van Dam R Michael, On-demand droplet loading for automated organic chemistry on digital microfluidics, Lab on a chip, 2013, 13 (14), 2785-95.
Sadeghi Saman, Liang Vincent, Cheung Shilin, Woo Suh, Wu Curtis, Ly Jimmy, Deng Yuliang, Eddings Mark, van Dam R Michael, Reusable electrochemical cell for rapid separation of [18F]fluoride from [18O]water for flow-through synthesis of 18F-labeled tracers, Applied radiation and isotopes, 2013, 75 (14), 85-94.
Claggett Shane B, Quinn Kevin M, Lazari Mark, Moore Melissa D, van Dam R Michael, Simplified programming and control of automated radiosynthesizers through unit operations, EJNMMI research, 2013, 3 (1), 53.
Lazari Mark, Quinn Kevin M, Claggett Shane B, Collins Jeffrey, Shah Gaurav J, Herman Henry E, Maraglia Brandon, Phelps Michael E, Moore Melissa D, van Dam R Michael, ELIXYS - a fully automated, three-reactor high-pressure radiosynthesizer for development and routine production of diverse PET tracers, EJNMMI research, 2013, 3 (1), 52.
Ma Xiaoxiao, Tseng Wei-Yu, Eddings Mark, Keng Pei Yuin, van Dam R Michael, A microreactor with phase-change microvalves for batch chemical synthesis at high temperatures and pressures, Lab on a chip, 2014, 14 (2), 280-5.
Cheung Shilin, Ly Jimmy, Lazari Mark, Sadeghi Saman, Keng Pei Yuin, van Dam R Michael, The separation and detection of PET tracers via capillary electrophoresis for chemical identity and purity analysis, Journal of pharmaceutical and biomedical analysis, 2014, 94 (13), 12-8.
Dooraghi Alex A, Keng Pei Y, Chen Supin, Javed Muhammad R, Kim Chang-Jin C J, Chatziioannou Arion F, van Dam R Michael, Optimization of microfluidic PET tracer synthesis with Cerenkov imaging, The Analyst, 2013, 138 (19), 5654-64.
Ly Jimmy, Masterman-Smith Michael, Ramakrishnan Ravichandran, Sun Jing, Kokubun Brent, van Dam R Michael, Automated reagent-dispensing system for microfluidic cell biology assays, Journal of laboratory automation, 2013, 18 (6), 530-41.
Chen Supin, Javed Muhammad Rashed, Kim Hee-Kwon, Lei Jack, Lazari Mark, Shah Gaurav J, van Dam R Michael, Keng Pei-Yuin, Kim Chang-Jin C J, Radiolabelling diverse positron emission tomography (PET) tracers using a single digital microfluidic reactor chip, Lab on a chip, 2014, 14 (5), 902-10.
Sergeev Maxim E, Morgia Federica, Lazari Mark, Wang Christopher, van Dam R Michael, Titania-catalyzed radiofluorination of tosylated precursors in highly aqueous medium, Journal of the American Chemical Society, 2015, 137 (17), 5686-94.
Javed Muhammad Rashed, Chen Supin, Lei Jack, Collins Jeffrey, Sergeev Maxim, Kim Hee-Kwon, Kim Chang-Jin, van Dam R Michael, Keng Pei Yuin, High yield and high specific activity synthesis of [18F]fallypride in a batch microfluidic reactor for micro-PET imaging, Chemical communications (Cambridge, England), 2014, 50 (10), 1192-4.
Lazari Mark, Collins Jeffrey, Shen Bin, Farhoud Mohammed, Yeh Daniel, Maraglia Brandon, Chin Frederick T, Nathanson David A, Moore Melissa, van Dam R Michael, Fully automated production of diverse 18F-labeled PET tracers on the ELIXYS multireactor radiosynthesizer without hardware modification, Journal of nuclear medicine technology, 2014, 42 (3), 203-10.
Javed Muhammad Rashed, Chen Supin, Kim Hee-Kwon, Wei Liu, Czernin Johannes, Kim Chang-Jin C J, van Dam R Michael, Keng Pei Yuin, Efficient radiosynthesis of 3'-deoxy-3'-18F-fluorothymidine using electrowetting-on-dielectric digital microfluidic chip, Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 2014, 55 (2), 321-8.
Tseng Wei-Yu, van Dam R Michael, Compact microfluidic device for rapid concentration of PET tracers, Lab on a chip, 2014, 14 (13), 2293-302.
Lazari Mark, Irribarren Jonathan, Zhang Shuang, van Dam R Michael, Understanding temperatures and pressures during short radiochemical reactions, Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine, 2016, 108, 82-91.
Keng Pei Yuin, van Dam R Michael, Digital Microfluidics: A New Paradigm for Radiochemistry, Molecular imaging, 2015, 14, 13-14.
Lazari Mark, Lyashchenko Serge K, Burnazi Eva M, Lewis Jason S, van Dam R Michael, Murphy Jennifer M, Fully-automated synthesis of 16β-(18)F-fluoro-5α-dihydrotestosterone (FDHT) on the ELIXYS radiosynthesizer, Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine, 2015, 103, 9-14.