California NanoSystems Institute
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Robert Damoiseaux, Ph.D.

Director, Molecular Screening Shared Resource (MSSR)

Ph.D., The University of Lausanne, Switzerland, 2001
M.S., Ruhr‑University Bochum, Germany, 1996

Contact Information:
Email Address:
Email Address:
Mailing Address: Mail Code: 148906
2805 Molecular Sciences Bldg.
Los Angeles, CA 90095
Work Address: Molecular Shared Screening Resource
California NanoSystems Institute
570 Westwood Plaza
Bldg 114
Los Angeles, CA 90095
Lab Number: 310-983-3004
Office Phone Number: 310-794-1974

Selected Publications:

Kim Kyun-Do, Srikanth Sonal, Tan Yossan-Var, Yee Ma-Khin, Jew Marcus, Damoiseaux Robert, Jung Michael E, Shimizu Saki, An Dong Sung, Ribalet Bernard, Waschek James A, Gwack Yousang, Calcium signaling via Orai1 is essential for induction of the nuclear orphan receptor pathway to drive Th17 differentiation, Journal of immunology (Baltimore, Md. : 1950), 2014, 192 (1), 110-22.
Meng H, Mai WX, Zhang H, Xue M, Xia T, Lin S, Wang X, Zhao Y, Ji Z, Zink JI, Nel AE, Damoiseaux, R., Codelivery of an optimal drug/siRNA combination using mesoporous silica nanoparticles to overcome drug resistance in breast cancer in vitro and in vivo, ACS Nano, 2013, 7 (2), 994-1005.
Solaimani Parrisa, Damoiseaux Robert, Hankinson Oliver, Genome-wide RNAi high-throughput screen identifies proteins necessary for the AHR-dependent induction of CYP1A1 by 2,3,7,8-tetrachlorodibenzo-p-dioxin, Toxicological sciences : an official journal of the Society of Toxicology, 2013, 136 (1), 107-19.
Du Liutao, Jung Michael E, Damoiseaux Robert, Completo Gladys, Fike Francesca, Ku Jin-Mo, Nahas Shareef, Piao Cijing, Hu Hailiang, Gatti Richard A, A new series of small molecular weight compounds induce read through of all three types of nonsense mutations in the ATM gene, Molecular therapy : the journal of the American Society of Gene Therapy, 2013, 21 (9), 1653-60.
Murphy Jennifer M, Armijo Amanda L, Nomme Julian, Lee Chi Hang, Smith Quentin A, Li Zheng, Campbell Dean O, Liao Hsiang-I, Nathanson David A, Austin Wayne R, Lee Jason T, Darvish Ryan, Wei Liu, Wang Jue, Su Ying, Damoiseaux Robert, Sadeghi Saman, Phelps Michael E, Herschman Harvey R, Czernin Johannes, Alexandrova Anastassia N, Jung Michael E, Lavie Arnon, Radu Caius G, Development of new deoxycytidine kinase inhibitors and noninvasive in vivo evaluation using positron emission tomography, Journal of medicinal chemistry, 2013, 56 (17), 6696-708.
Zheng Sika, Damoiseaux Robert, Chen Liang, Black Douglas L, A broadly applicable high-throughput screening strategy identifies new regulators of Dlg4 (Psd-95) alternative splicing, Genome research, 2013, 23 (6), 998-1007.
Xiong Sijing, George Saji, Yu Haiyang, Damoiseaux Robert, France Bryan, Ng Kee Woei, Loo Joachim Say-Chye, Size influences the cytotoxicity of poly (lactic-co-glycolic acid) (PLGA) and titanium dioxide (TiO(2)) nanoparticles, Archives of toxicology, 2013, 87 (6), 1075-86.
Dabir Deepa V, Hasson Samuel A, Setoguchi Kiyoko, Johnson Meghan E, Wongkongkathep Piriya, Douglas Colin J, Zimmerman Johannes, Damoiseaux Robert, Teitell Michael A, Koehler Carla M, A small molecule inhibitor of redox-regulated protein translocation into mitochondria, Developmental cell, 2013, 25 (1), 81-92.
Fung Eileen, Sugianto Priscilla, Hsu Jason, Damoiseaux Robert, Ganz Tomas, Nemeth Elizabeta, High-throughput screening of small molecules identifies hepcidin antagonists, Molecular pharmacology, 2013, 83 (3), 681-90.
Xiong Sijing, George Saji, Ji Zhaoxia, Lin Sijie, Yu Haiyang, Damoiseaux Robert, France Bryan, Ng Kee Woei, Loo Say Chye Joachim, Size of TiO(2) nanoparticles influences their phototoxicity: an in vitro investigation, Archives of toxicology, 2013, 87 (1), 99-109.
Zhang Haiyuan, Ji Zhaoxia, Xia Tian, Meng Huan, Low-Kam Cecile, Liu Rong, Pokhrel Suman, Lin Sijie, Wang Xiang, Liao Yu-Pei, Wang Meiying, Li Linjiang, Rallo Robert, Damoiseaux Robert, Telesca Donatello, Mädler Lutz, Cohen Yoram, Zink Jeffrey I, Nel Andre E, Use of Metal Oxide Nanoparticle Band Gap To Develop a Predictive Paradigm for Oxidative Stress and Acute Pulmonary Inflammation, ACS nano, 2012.
Miraglia Loren, King Fred, Damoiseaux Robert, Seeing the Light: Luminescent Reporter Gene Assays, Combinatorial chemistry & high throughput screening, 2011.
Zhang Haiyuan, Xia Tian, Meng Huan, Xue Min, George Saji, Ji Zhaoxia, Wang Xiang, Liu Rong, Wang Meiying, France Bryan, Rallo Robert, Damoiseaux Robert, Cohen Yoram, Bradley Kenneth A, Zink Jeffrey I, Nel Andre E, Differential expression of syndecan-1 mediates cationic nanoparticle toxicity in undifferentiated versus differentiated normal human bronchial epithelial cells, ACS nano, 2011, 5 (4), 2756-69.
Damoiseaux R, George S, Li M, Pokhrel S, Ji Z, France B, Xia T, Suarez E, Rallo R, Mädler L, Cohen Y, Hoek E M V, Nel A, No time to lose--high throughput screening to assess nanomaterial safety, Nanoscale, 2011, 3 (4), 1345-60.
Kim Kwanghee, Damoiseaux Robert, Norris Andrew J, Rivina Leena, Bradley Kenneth, Jung Michael E, Gatti Richard A, Schiestl Robert H, McBride William H, High throughput screening of small molecule libraries for modifiers of radiation responses, International journal of radiation biology, 2011, 5 (3).
George Saji, Xia Tian, Rallo Robert, Zhao Yan, Ji Zhaoxia, Lin Sijie, Wang Xiang, Zhang Haiyuan, France Bryan, Schoenfeld David, Damoiseaux Robert, Liu Rong, Lin Shuo, Bradley Kenneth A, Cohen Yoram, Nel André E, Use of a high-throughput screening approach coupled with in vivo zebrafish embryo screening to develop hazard ranking for engineered nanomaterials, ACS nano, 2011, 5 (3), 1805-17.
Walter Martin A, Benz Matthias R, Hildebrandt Isabel J, Laing Rachel E, Hartung Verena, Damoiseaux Robert D, Bockisch Andreas, Phelps Michael E, Czernin Johannes, Weber Wolfgang A, Metabolic imaging allows early prediction of response to vandetanib, Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 2011, 52 (2), 231-40.
Kamei Ken-ichiro, Sun Jing, Tseng Hsian-Rong, Damoiseaux Robert, Microfluidic image cytometry, Methods in molecular biology (Clifton, N.J.), 2011, 706 (2), 191-206.
Rallo Robert, France Bryan, Liu Rong, Nair Sumitra, George Saji, Damoiseaux Robert, Giralt Francesc, Nel Andre, Bradley Kenneth, Cohen Yoram, Self-Organizing Map Analysis of Toxicity-Related Cell Signaling Pathways for Metal and Metal Oxide Nanoparticles, Environmental science & technology, 2011, 52 (2).
Li Minghua, Pokhrel Suman, Jin Xue, Mädler Lutz, Damoiseaux Robert, Hoek Eric M V, Stability, bioavailability, and bacterial toxicity of ZnO and iron-doped ZnO nanoparticles in aquatic media, Environmental science & technology, 2011, 45 (2), 755-61.
Jin Xue, Li Minghua, Wang Jinwen, Marambio-Jones Catalina, Peng Fubing, Huang Xiaofei, Damoiseaux Robert, Hoek Eric M V, High-throughput screening of silver nanoparticle stability and bacterial inactivation in aquatic media: influence of specific ions, Environmental science & technology, 2010, 44 (19), 7321-8.
Peng Fubing, Hoek Eric M V, Damoiseaux Robert, High-content screening for biofilm assays, Journal of biomolecular screening, 2010, 15 (7), 748-54.
Aghajan Mariam, Jonai Nao, Flick Karin, Fu Fei, Luo Manlin, Cai Xiaolu, Ouni Ikram, Pierce Nathan, Tang Xiaobo, Lomenick Brett, Damoiseaux Robert, Hao Rui, Del Moral Pierre M, Verma Rati, Li Ying, Li Cheng, Houk Kendall N, Jung Michael E, Zheng Ning, Huang Lan, Deshaies Raymond J, Kaiser Peter, Huang Jing, Chemical genetics screen for enhancers of rapamycin identifies a specific inhibitor of an SCF family E3 ubiquitin ligase, Nature biotechnology, 2010, 28 (7), 738-42.
Hasson Samuel A, Damoiseaux Robert, Glavin Jenny D, Dabir Deepa V, Walker Scott S, Koehler Carla M, Substrate specificity of the TIM22 mitochondrial import pathway revealed with small molecule inhibitor of protein translocation, Proceedings of the National Academy of Sciences of the United States of America, 2010, 107 (21), 9578-83.
Wolf Mike C, Freiberg Alexander N, Zhang Tinghu, Akyol-Ataman Zeynep, Grock Andrew, Hong Patrick W, Li Jianrong, Watson Natalya F, Fang Angela Q, Aguilar Hector C, Porotto Matteo, Honko Anna N, Damoiseaux Robert, Miller John P, Woodson Sara E, Chantasirivisal Steven, Fontanes Vanessa, Negrete Oscar A, Krogstad Paul, Dasgupta Asim, Moscona Anne, Hensley Lisa E, Whelan Sean P, Faull Kym F, Holbrook Michael R, Jung Michael E, Lee Benhur, A broad-spectrum antiviral targeting entry of enveloped viruses, Proceedings of the National Academy of Sciences of the United States of America, 2010, 107 (7), 3157-62.
Lee Delphine J, Li Huiying, Ochoa Maria T, Tanaka Motoyuki, Carbone Ryan J, Damoiseaux Robert, Burdick Anne, Sarno Euzenir N, Rea Thomas H, Modlin Robert L, Integrated pathways for neutrophil recruitment and inflammation in leprosy, The Journal of infectious diseases, 2010, 201 (4), 558-69.
Ohno Izumi, Eibl Guido, Odinokova Irina, Edderkaoui Mouad, Damoiseaux Robert D, Yazbec Moussa, Abrol Ravinder, Goddard William A, Yokosuka Osamu, Pandol Stephen J, Gukovskaya Anna S, Rottlerin stimulates apoptosis in pancreatic cancer cells through interactions with proteins of the Bcl-2 family, American journal of physiology. Gastrointestinal and liver physiology, 2010, 298 (1), G63-73.
George Saji, Pokhrel Suman, Xia Tian, Gilbert Benjamin, Ji Zhaoxia, Schowalter Marco, Rosenauer Andreas, Damoiseaux Robert, Bradley Kenneth A, Mädler Lutz, Nel André E, Use of a rapid cytotoxicity screening approach to engineer a safer zinc oxide nanoparticle through iron doping, ACS nano, 2010, 4 (1), 15-29.
Kim Kwanghee, Pollard Julianne M, Norris Andrew J, McDonald J Tyson, Sun Yingli, Micewicz Ewa, Pettijohn Kelly, Damoiseaux Robert, Iwamoto Keisuke S, Sayre James W, Price Brendan D, Gatti Richard A, McBride William H, High-throughput screening identifies two classes of antibiotics as radioprotectors: tetracyclines and fluoroquinolones, Clinical cancer research : an official journal of the American Association for Cancer Research, 2009, 15 (23), 7238-45.
Suree Nuttee, Yi Sung Wook, Thieu William, Marohn Melanie, Damoiseaux Robert, Chan Albert, Jung Michael E, Clubb Robert T, Discovery and structure-activity relationship analysis of Staphylococcus aureus sortase A inhibitors, Bioorganic & medicinal chemistry, 2009, 17 (20), 7174-85.
Du Liutao, Damoiseaux Robert, Nahas Shareef, Gao Kun, Hu Hailiang, Pollard Julianne M, Goldstine Jimena, Jung Michael E, Henning Susanne M, Bertoni Carmen, Gatti Richard A, Nonaminoglycoside compounds induce readthrough of nonsense mutations, The Journal of experimental medicine, 2009, 206 (10), 2285-97.
Damoiseaux Robert, Sherman Sean P, Alva Jackelyn A, Peterson Cory, Pyle April D, Integrated chemical genomics reveals modifiers of survival in human embryonic stem cells, Stem cells (Dayton, Ohio), 2009, 27 (3), 533-42.
Poulos Jason L, Jeon Tae-Joon, Damoiseaux Robert, Gillespie Eugene J, Bradley Kenneth A, Schmidt Jacob J, Ion channel and toxin measurement using a high throughput lipid membrane platform, Biosensors & bioelectronics, 2009, 24 (6), 1806-10.
Stoilov Peter, Lin Chia-Ho, Damoiseaux Robert, Nikolic Julia, Black Douglas L, A high-throughput screening strategy identifies cardiotonic steroids as alternative splicing modulators, Proceedings of the National Academy of Sciences of the United States of America, 2008, 105 (32), 11218-23.
Lee Shaoying, Deng Hongyu, Yu Fuqu, Melega William P, Damoiseaux Robert, Bradley Kenneth A, Sun Ren, Regulation of Kaposi's sarcoma-associated herpesvirus reactivation by dopamine receptor-mediated signaling pathways, Journal of acquired immune deficiency syndromes (1999), 2008, 48 (5), 531-40.
Sanchez Ana M, Thomas Diane, Gillespie Eugene J, Damoiseaux Robert, Rogers Joseph, Saxe Jonathan P, Huang Jing, Manchester Marianne, Bradley Kenneth A, Amiodarone and bepridil inhibit anthrax toxin entry into host cells, Antimicrobial agents and chemotherapy, 2007, 51 (7), 2403-11.
Waki Hironori, Park Kye Won, Mitro Nico, Pei Liming, Damoiseaux Robert, Wilpitz Damien C, Reue Karen, Saez Enrique, Tontonoz Peter, The small molecule harmine is an antidiabetic cell-type-specific regulator of PPARgamma expression, Cell metabolism, 2007, 5 (5), 357-70.
Wu Xinrong, Zhong Hanbing, Song Jianbo, Damoiseaux Robert, Yang Zhen, Lin Shuo, Mycophenolic acid is a potent inhibitor of angiogenesis, Arteriosclerosis, thrombosis, and vascular biology, 2006, 26 (10), 2414-6.
Kamata Masakazu, Wu Raymond P, An Dong Sung, Saxe Jonathan P, Damoiseaux Robert, Phelps Michael E, Huang Jing, Chen Irvin S Y, Cell-based chemical genetic screen identifies damnacanthal as an inhibitor of HIV-1 Vpr induced cell death, Biochemical and biophysical research communications, 2006, 348 (3), 1101-6.
Winssinger Nicolas, Damoiseaux Robert, Tully David C, Geierstanger Bernhard H, Burdick Keith, Harris Jennifer L, PNA-encoded protease substrate microarrays, Chemistry & biology, 2004, 11 (10), 1351-60.
Warmuth Markus, Damoiseaux Robert, Liu Yi, Fabbro Doriano, Gray Nathanael, SRC family kinases: potential targets for the treatment of human cancer and leukemia, Current pharmaceutical design, 2003, 9 (25), 2043-59.
Damoiseaux Robert, Schultz Peter G, Johnsson Kai, Towards the generation of artificial O6-alkylguanine-DNA alkyltransferases: in vitro selection of antibodies with reactive cysteine residues, Chembiochem : a European journal of chemical biology, 2002, 3 (6), 573-5.