California NanoSystems Institute
CNSI
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William Klug, Ph.D.

   
Associate Professor, Mechanical and Aerospace Engineering
Member, California NanoSystems Institute

Education:
Degrees:
Ph.D., California Institute of Technology, 2003
M.S., University of California Los Angeles, 1990
B.S., Westmont College, 1997

Honors and Awards:
2008 - 2013 National Science Foundation, NSF CAREER Award
1999 - 2003 Caltech Doctoral Award (including Betty and Gordon Moore Fellowship)
1998 Chi Epsilon Civil Engineering Honor Society
1997 Santa Barbara & Ventura Counties, Engineering Student of the Year Scholarship
1997 Omicron Delta Kappa National Leadership Society
1994 - 1997 Westmont College Presidential Scholarship

Contact Information:
Email Address: klug@ucla.edu
Work Email Address: klug@seas.ucla.edu
Mailing Address: 420 Westwood Plaza
Room 48-121B
Los Angeles, CA 90095
UNITED STATES
Home Page: http://www.seas.ucla.edu/%7Eklug/
Fax Number: (310) 206-4830 FAX
Work Phone Number: (310) 794-7347 Office
Technical Research Interest:

My group is primarily interested in theoretical and computational biomechanics. In particular, we are developing continuum and multiscale methods to understand the mechanics of biological structures from the molecular and cellular scales upward. Some of our projects are listed below.

Mechanics of viruses and macromolecular assemblies
We are developing coarse-grained continuum theories and multiscale simulation methodologies to study the mechanics of macromolecules (proteins and nucleic acids) and macromolecular assemblies. The protein shells (capsids) of viruses are the main focus of our efforts.

Mechanics of biomembranes
We are studying the mechanics of lipid bilayer membranes under the influence of externally applied loadings, developing models to account for "realistic" biological complexities such as mixtures of lipids, intermembrane proteins, and interaction with the cytoskeleton.

Continuum Modeling of DNA
With Michael Ortiz I've developed a director field model of DNA packaging of viral capsids. Analytical and numerical optimization techniques were employed to identify energy minimizing packaged configurations of viral DNA. Check out my Ph.D. thesis

Cardiac ElectroMechanics
With Alan Garfinkel (UCLA Cardiology), and Daniel Ennis (UCLA Radiology) we are developing finite element techniques for coupling electrophysiology with the mechanics of contraction for the human heart. We are working to understand the complex dynamics of fibrilation, and the effects of fibrosis, hypertropy, dilatation, and other markers of heart disease on the physical function of the heart.

Active, Motor-driven Mechanics of Semiflexible Gels and the Cytoskeleton
In collaboration with CNSI colleage Alex Levine we are using finite-element computational methods to study the physical properties of cross-linked networks of semiflexible polymer filaments. We are interested in the non-equilibrium effects of pre-stress generated by molecular motors on the nonlinear elastic properties of these gels.




Additional Information:

William Klug is an Associate Professor in the Mechanical and Aerospace Engineering Department at UCLA, where he has been since 2003. He received a B.S. in Engineering Physics from Westmont College in 1997, a M.S. in Civil Engineering from UCLA in 1999, and a Ph.D. from Caltech in 2003. He is the recipient of a 2007 NSF CAREER award. Professor Klug's primary scientific background is in continuum and computational modeling of the mechanics of solids and structures. He has particular experience in the development of numerical methods for modeling thin beam- and shell-like structures, and in the application of those methods to multi-physics problems in biology, from the macroscale to the nanoscale.

Selected Publications:

Andrew R. Missel, Mo Bai, William S. Klug, and Alex J. Levine, Affine-nonaffine transition in networks of nematically ordered semiflexible polymers, Phys. Rev. E, 2010, 82 (4).
Morozov AY, Rudnick J, Bruinsma RF and Klug WS, Assembly and Disassembly of Deltahedral Viral Shells, Emerging Topics in Physical Virology , 2010, 159-83.
Roos WH, Gibbons MM, Arkhipov A, Uetrecht C, Watts NR, Wingfield PT, Steven AC, Heck AJ, Schulten K, Klug WS, Wuite GJ, Squeezing protein shells: how continuum elastic models, molecular dynamics simulations, and experiments coalesce at the nanoscale, Biophys J, 2010, 99 (4), 1175-81.
Hoshino Tetsuya, Chow Lori A, Hsu Jeffrey J, Perlowski Alice A, Abedin Moeen, Tobis Jonathan, Tintut Yin, Mal Ajit K, Klug William S, Demer Linda L, Mechanical stress analysis of a rigid inclusion in distensible material: a model of atherosclerotic calcification and plaque vulnerability, American journal of physiology. Heart and circulatory physiology, 2009, 297 (2), H802-10.
Ursell Tristan S, Klug William S, Phillips Rob, Morphology and interaction between lipid domains, Proceedings of the National Academy of Sciences of the United States of America, 2009, 106 (32), 13301-6.
Gibbons, M. M. Klug, W. S., Influence of nonuniform geometry on nanoindentation of viral capsids, Biophys J, 2008, 95 (8), 3640-9.
Lee Heun Jin, Peterson Eric L, Phillips Rob, Klug William S, Wiggins Paul A, Membrane shape as a reporter for applied forces, Proceedings of the National Academy of Sciences of the United States of America, 2008, 105 (49), 19253-7.
Wilkinson, P. R. Klug, W. S. Van Leer, B. Gimzewski, J. K., Nanomechanical properties of piezoresistive cantilevers: Theory and experiment, Journal of Applied Physics, 2008, 104 (10).
Gibbons, M.M. and Klug, W.S., Mechanical Modeling of Viral Capsids, Journal of Material Science, 2007, 42 (21), 8995-9004.
Gibbons, M. M. Klug, W. S., Nonlinear finite-element analysis of nanoindentation of viral capsids, Phys Rev E Stat Nonlin Soft Matter Phys, 2007, 75 (3 Pt 1), 031901.
Klug, W. S. Bruinsma, R. F. Michel, J. P. Knobler, C. M. Ivanovska, I. L. Schmidt, C. F. Wuite, G. J., Failure of viral shells, Phys Rev Lett, 2006, 97 (22), 228101.
Feng, F. and Klug, W.S., Finite Element Modeling of Lipid Bilayer Membranes, J. Comp. Phys, 2006, 20 (1), 394-408.
Michel, J.-P., Ivanovska, I.L., Gibbons, M.M., Klug, W.S., Knobler, C.M., Wuite, G.J.L., and Schmidt, C.F., Nanoindentation Studies of Full and Empty Viral Capsids and the Effects of Capsid Protein Mutations on Elasticity and Strength, Proc. Nat. Acad. Sci. USA, 2006, 103 (16), 6184-6189.
W.S. Klug, M.T. Feldmann, M. Ortiz, Three-dimensional director-field predictions of viral DNA packing arrangements, Computational Mechanics, 2005, 35 (2), 146-152.
W. S. Klug, M. Ortiz, A Director Field Model of DNA Packaging in Viral Capsids, Journal of Mechanics and Physics of Solids, 2003, 51 (10), 1815-1847.
A. Mota, W. Klug, A. Pandolfi, M. Ortiz, Finite Element Simulation of Firearm Injury to the Human Cranium, Computational Mechanics, 2003, 31 (1-2), 115-121.