California NanoSystems Institute
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Yibin Wang, Ph.D.

Professor, Medicine, Anesthesiology

Ph.D., Baylor College of Medicine, 1993
B.S., New York State University, 1988 -

Contact Information:
Work Email Address:
Work Email Address:
Mailing Address: Laboratory
UCLA, David Geffen School of Medicine
Department of Anesthesiology
Division of Molecular Medicine
650 Charles E Young Dr.
Los Angeles, CA 90095
Work Address: Office
CHS BH-569
Campus - 711520
Home Page:
Work Phone Number: (310)2065197

Selected Publications:

Touma, M.; Kang, X.; Zhao, Y.; Cass, A. A.; Gao, F.; Biniwale, R.; Coppola, G.; Xiao, X.; Reemtsen, B.; Wang, Y., Decoding the Long Noncoding RNA During Cardiac Maturation: A Roadmap for Functional Discovery, Circ Cardiovasc Genet, 2016, 9 (5), 395-407.
Wang, J. J.; Rau, C.; Avetisyan, R.; Ren, S.; Romay, M. C.; Stolin, G.; Gong, K. W.; Wang, Y.; Lusis, A. J., Genetic Dissection of Cardiac Remodeling in an Isoproterenol-Induced Heart Failure Mouse Model, PLoS Genet, 2016, 12 (7), e1006038.
Gao, C.; Wang, Y., Positive Role for a Negative Calcineurin Regulator in Cardiac Hypertrophy, Hypertension, 2016, 67 (5), 841-2.
Gao, C.; Ren, S.; Lee, J. H.; Qiu, J.; Chapski, D. J.; Rau, C. D.; Zhou, Y.; Abdellatif, M.; Nakano, A.; Vondriska, T. M.; Xiao, X.; Fu, X. D.; Chen, J. N.; Wang, Y., RBFox1-mediated RNA splicing regulates cardiac hypertrophy and heart failure, J Clin Invest, 2016, 126 (1), 195-206.
Lusis, A. J.; Seldin, M. M.; Allayee, H.; Bennett, B. J.; Civelek, M.; Davis, R. C.; Eskin, E.; Farber, C. R.; Hui, S.; Mehrabian, M.; Norheim, F.; Pan, C.; Parks, B.; Rau, C. D.; Smith, D. J.; Vallim, T.; Wang, Y.; Wang, J., The Hybrid Mouse Diversity Panel: a resource for systems genetics analyses of metabolic and cardiovascular traits, J Lipid Res, 2016, 57 (6), 925-42.
Wang, Z.; Zhang, X. J.; Ji, Y. X.; Zhang, P.; Deng, K. Q.; Gong, J.; Ren, S.; Wang, X.; Chen, I.; Wang, H.; Gao, C.; Yokota, T.; Ang, Y. S.; Li, S.; Cass, A.; Vondriska, T. M.; Li, G.; Deb, A.; Srivastava, D.; Yang, H. T.; Xiao, X.; Li, H.; Wang, Y., The long noncoding RNA Chaer defines an epigenetic checkpoint in cardiac hypertrophy, Nat Med, 2016, 22 (10), 1131-1139.
Rau, C. D.; Romay, M. C.; Tuteryan, M.; Wang, J. J.; Santolini, M.; Ren, S.; Karma, A.; Weiss, J. N.; Wang, Y.; Lusis, A. J., Systems Genetics Approach Identifies Gene Pathways and Adamts2 as Drivers of Isoproterenol-Induced Cardiac Hypertrophy and Cardiomyopathy in Mice, Cell Syst, 2016.
Pillai, I. C.; Li, S.; Romay, M.; Lam, L.; Lu, Y.; Huang, J.; Dillard, N.; Zemanova, M.; Rubbi, L.; Wang, Y.; Lee, J.; Xia, M.; Liang, O.; Xie, Y. H.; Pellegrini, M.; Lusis, A. J.; Deb, A., Cardiac Fibroblasts Adopt Osteogenic Fates and Can Be Targeted to Attenuate Pathological Heart Calcification, Cell Stem Cell, 2016.
Dong, W.; Zhou, M.; Dong, M.; Pan, B.; Liu, Y.; Shao, J.; Gu, X.; Huang, Y.; Li, G.; Wang, Y.; Sun, H., Keto acid metabolites of branched-chain amino acids inhibit oxidative stress-induced necrosis and attenuate myocardial ischemia-reperfusion injury, J Mol Cell Cardiol, 2016, 101, 90-98.
Franklin, S.; Kimball, T.; Rasmussen, T. L.; Rosa-Garrido, M.; Chen, H.; Tran, T.; Miller, M. R.; Gray, R.; Jiang, S.; Ren, S.; Wang, Y.; Tucker, H. O.; Vondriska, T. M., The chromatin-binding protein Smyd1 restricts adult mammalian heart growth, Am J Physiol Heart Circ Physiol, 2016, 311 (5), H1234-H1247.
Wang, J. J.; Aboulhosn, J. A.; Hofer, I. S.; Mahajan, A.; Wang, Y.; Vondriska, T. M., Operationalizing Precision Cardiovascular Medicine: Three Innovations, Circ Res, 2016, 119 (9), 984-987.
Rau, C. D.; Gao, C.; Wang, Y., Deconvolution of the Human Endothelial Transcriptome, Cell Syst, 2016, 3 (3), 218-220.
Sun, H.; Wang, Y., Branched chain amino acid metabolic reprogramming in heart failure, Biochim Biophys Acta, 2016.
Karbassi, E.; Monte, E.; Chapski, D. J.; Lopez, R.; Rosa Garrido, M.; Kim, J.; Wisniewski, N.; Rau, C. D.; Wang, J. J.; Weiss, J. N.; Wang, Y.; Lusis, A. J.; Vondriska, T. M., Relationship of disease-associated gene expression to cardiac phenotype is buffered by genetic diversity and chromatin regulation, Physiol Genomics, 2016, 48 (8), 601-15.
Monte, E.; Rosa-Garrido, M.; Karbassi, E.; Chen, H.; Lopez, R.; Rau, C. D.; Wang, J.; Nelson, S. F.; Wu, Y.; Stefani, E.; Lusis, A. J.; Wang, Y.; Kurdistani, S. K.; Franklin, S.; Vondriska, T. M., Reciprocal Regulation of the Cardiac Epigenome by Chromatin Structural Proteins Hmgb and Ctcf: IMPLICATIONS FOR TRANSCRIPTIONAL REGULATION, J Biol Chem, 2016, 291 (30), 15428-46.
Sun, H.; Olson, K. C.; Gao, C.; Prosdocimo, D. A.; Zhou, M.; Wang, Z.; Jeyaraj, D.; Youn, J. Y.; Ren, S.; Liu, Y.; Rau, C. D.; Shah, S.; Ilkayeva, O.; Gui, W. J.; William, N. S.; Wynn, R. M.; Newgard, C. B.; Cai, H.; Xiao, X.; Chuang, D. T.; Schulze, P. C.; Lynch, C.; Jain, M. K.; Wang, Y., Catabolic Defect of Branched-Chain Amino Acids Promotes Heart Failure, Circulation, 2016, 133 (21), 2038-49.
Cong, Q.; Jia, H.; Biswas, S.; Li, P.; Qiu, S.; Deng, Q.; Guo, X.; Ma, G.; Ling Chau, J. F.; Wang, Y.; Zhang, Z. L.; Jiang, X.; Liu, H.; Li, B., p38alpha MAPK Regulates Lineage Commitment and OPG Synthesis of Bone Marrow Stromal Cells to Prevent Bone Loss under Physiological and Pathological Conditions, Stem Cell Reports, 2016, 6 (4), 566-78.
Chen, H.; Orozco, L. D.; Wang, J.; Rau, C. D.; Rubbi, L.; Ren, S.; Wang, Y.; Pellegrini, M.; Lusis, A. J.; Vondriska, T. M., DNA Methylation Indicates Susceptibility to Isoproterenol-Induced Cardiac Pathology and Is Associated With Chromatin States, Circ Res, 2016, 118 (5), 786-97.
Iorga, A.; Li, J.; Sharma, S.; Umar, S.; Bopassa, J. C.; Nadadur, R. D.; Centala, A.; Ren, S.; Saito, T.; Toro, L.; Wang, Y.; Stefani, E.; Eghbali, M., Rescue of Pressure Overload-Induced Heart Failure by Estrogen Therapy, J Am Heart Assoc, 2016, 5 (1).
Yokota, Tomohiro; Wang, Yibin, p38 MAP kinases in the heart, Gene, 2016, 575 (2), 369-376.
Song, Y.; Zhang, Y.; Jiang, H.; Zhu, Y.; Liu, L.; Feng, W.; Yang, L.; Wang, Y.; Li, M., Activation of Notch3 promotes pulmonary arterial smooth muscle cells proliferation via Hes1/p27Kip1 signaling pathway, FEBS Open Bio, 2015, 5, 656-60.
Rau, C. D.; Lusis, A. J.; Wang, Y., Genetics of common forms of heart failure: challenges and potential solutions, Curr Opin Cardiol, 2015, 30 (3), 222-7.
Rau, C. D.; Parks, B.; Wang, Y.; Eskin, E.; Simecek, P.; Churchill, G. A.; Lusis, A. J., High-Density Genotypes of Inbred Mouse Strains: Improved Power and Precision of Association Mapping, G3 (Bethesda), 2015, 5 (10), 2021-6.
Cai, R.; Gu, J.; Sun, H.; Liu, X.; Mei, W.; Qi, Y.; Xue, S.; Ren, S.; Rabinowitz, J. E.; Wang, Y.; Yeh, E. T.; Cheng, J., Induction of SENP1 in myocardium contributes to abnormities of mitochondria and cardiomyopathy, J Mol Cell Cardiol, 2015, 79, 115-22.
Feng, J.; Gong, D.; Fu, X.; Wu, T. T.; Wang, J.; Chang, J.; Zhou, J.; Lu, G.; Wang, Y.; Sun, R., M1 of Murine Gamma-Herpesvirus 68 Induces Endoplasmic Reticulum Chaperone Production, Sci Rep, 2015, 5, 17228.
Rau, C. D.; Wang, J.; Avetisyan, R.; Romay, M. C.; Martin, L.; Ren, S.; Wang, Y.; Lusis, A. J., Mapping genetic contributions to cardiac pathology induced by Beta-adrenergic stimulation in mice, Circ Cardiovasc Genet, 2015, 8 (1), 40-9.
Neelankavil, J.; Rau, C. D.; Wang, Y., The Genetic Basis of Coronary Artery Disease and Atrial Fibrillation: A Search for Disease Mechanisms and Therapeutic Targets, J Cardiothorac Vasc Anesth, 2015, 29 (5), 1328-32.
Sun, H.; Wang, Y., The elusive philosopher's stone in young blood, Circ Res, 2015, 117 (11), 906-8.
Cattin, M. E.; Wang, J.; Weldrick, J. J.; Roeske, C. L.; Mak, E.; Thorn, S. L.; DaSilva, J. N.; Wang, Y.; Lusis, A. J.; Burgon, P. G., Deletion of MLIP (Muscle-enriched A-type Lamin-interacting Protein) Leads to Cardiac Hyperactivation of Akt/Mammalian Target of Rapamycin (mTOR) and Impaired Cardiac Adaptation, J Biol Chem, 2015, 290 (44), 26699-714.
Sun, H.; Gao, C.; Wang, Y., A H(a)rd Way to Adapt in Cardiac Hypertrophy, Circ Res, 2015, 117 (6), 484-6.
Deb, A.; Wang, Y., Hypertrophic preconditioning: short-term tricks for long-term gain, Circulation, 2015, 131 (17), 1468-70.
Wang, Z.; Wang, Y., Dawn of the Epi-LncRNAs: new path from Myheart, Circ Res, 2015, 116 (2), 235-6.
Ren, S.; Lu, G.; Ota, A.; Zhou, Z. H.; Vondriska, T. M.; Lane, T. F.; Wang, Y., IRE1 phosphatase PP2Ce regulates adaptive ER stress response in the postpartum mammary gland, PLoS One, 2014, 9 (11), e111606.
Sun, H.; Wang, Y., Interferon regulatory factors in heart: stress response beyond inflammation, Hypertension, 2014, 63 (4), 663-4.
Lam, M. P.; Wang, D.; Lau, E.; Liem, D. A.; Kim, A. K.; Ng, D. C.; Liang, X.; Bleakley, B. J.; Liu, C.; Tabaraki, J. D.; Cadeiras, M.; Wang, Y.; Deng, M. C.; Ping, P., Protein kinetic signatures of the remodeling heart following isoproterenol stimulation, J Clin Invest, 2014, 124 (4), 1734-44.
Gao, C.; Wang, Y., Transcriptome complexity in cardiac development and diseases--an expanding universe between genome and phenome, Circ J, 2014, 78 (5), 1038-47.
Briot, A.; Jaroszewicz, A.; Warren, C. M.; Lu, J.; Touma, M.; Rudat, C.; Hofmann, J. J.; Airik, R.; Weinmaster, G.; Lyons, K.; Wang, Y.; Kispert, A.; Pellegrini, M.; Iruela-Arispe, M. L., Repression of Sox9 by Jag1 is continuously required to suppress the default chondrogenic fate of vascular smooth muscle cells, Dev Cell, 2014, 31 (6), 707-21.
Wang, Y., Blind dates in sciences: dealing with rejection in peer review, Circ Res, 2014, 114 (6), 944-6.
Xiao, X. G.; Touma, M.; Wang, Y., Decoding the noncoding transcripts in human heart failure, Circulation, 2014, 129 (9), 958-60.
Gupta, A.; Rohlfsen, C.; Leppo, M. K.; Chacko, V. P.; Wang, Y.; Steenbergen, C.; Weiss, R. G., Creatine kinase-overexpression improves myocardial energetics, contractile dysfunction and survival in murine doxorubicin cardiotoxicity, PLoS One, 2013, 8 (10), e74675.
Foster, W. H.; Langenbacher, A.; Gao, C.; Chen, J.; Wang, Y., Nuclear phosphatase PPM1G in cellular survival and neural development, Dev Dyn, 2013, 242 (9), 1101-9.
Lu, G.; Ota, A.; Ren, S.; Franklin, S.; Rau, C. D.; Ping, P.; Lane, T. F.; Zhou, Z. H.; Reue, K.; Lusis, A. J.; Vondriska, T.; Wang, Y., PPM1l encodes an inositol requiring-protein 1 (IRE1) specific phosphatase that regulates the functional outcome of the ER stress response, Mol Metab, 2013, 2 (4), 405-16.
Monte, E.; Mouillesseaux, K.; Chen, H.; Kimball, T.; Ren, S.; Wang, Y.; Chen, J. N.; Vondriska, T. M.; Franklin, S., Systems proteomics of cardiac chromatin identifies nucleolin as a regulator of growth and cellular plasticity in cardiomyocytes, Am J Physiol Heart Circ Physiol, 2013, 305 (11), H1624-38.
Force, T.; Wang, Y., Mechanism-based engineering against anthracycline cardiotoxicity, Circulation, 2013, 128 (2), 98-100.
Ahuja, P.; Wanagat, J.; Wang, Z.; Wang, Y.; Liem, D. A.; Ping, P.; Antoshechkin, I. A.; Margulies, K. B.; Maclellan, W. R., Divergent mitochondrial biogenesis responses in human cardiomyopathy, Circulation, 2013, 127 (19), 1957-67.
Li, J.; Umar, S.; Iorga, A.; Youn, J. Y.; Wang, Y.; Regitz-Zagrosek, V.; Cai, H.; Eghbali, M., Cardiac vulnerability to ischemia/reperfusion injury drastically increases in late pregnancy, Basic Res Cardiol, 2012, 107 (4), 271.
Gao, C.; Wang, Y., Global impact of RNA splicing on transcriptome remodeling in the heart, J Zhejiang Univ Sci B, 2012, 13 (8), 603-8.
Ghazalpour, A.; Rau, C. D.; Farber, C. R.; Bennett, B. J.; Orozco, L. D.; van Nas, A.; Pan, C.; Allayee, H.; Beaven, S. W.; Civelek, M.; Davis, R. C.; Drake, T. A.; Friedman, R. A.; Furlotte, N.; Hui, S. T.; Jentsch, J. D.; Kostem, E.; Kang, H. M.; Kang, E. Y.; Joo, J. W.; Korshunov, V. A.; Laughlin, R. E.; Martin, L. J.; Ohmen, J. D.; Parks, B. W.; Pellegrini, M.; Reue, K.; Smith, D. J.; Tetradis, S.; Wang, J.; Wang, Y.; Weiss, J. N.; Kirchgessner, T.; Gargalovic, P. S.; Eskin, E.; Lusis, A. J.; LeBoeuf, R. C., Hybrid mouse diversity panel: a panel of inbred mouse strains suitable for analysis of complex genetic traits, Mamm Genome, 2012, 23 (9-10), 680-92.
Sun, H.; Wang, Y., Novel Ser/Thr protein phosphatases in cell death regulation, Physiology (Bethesda), 2012, 27 (1), 43-52.
Franklin, S.; Chen, H.; Mitchell-Jordan, S.; Ren, S.; Wang, Y.; Vondriska, T. M., Quantitative analysis of the chromatin proteome in disease reveals remodeling principles and identifies high mobility group protein B2 as a regulator of hypertrophic growth, Mol Cell Proteomics, 2012, 11 (6), M111 014258.
MacLellan, W. R.; Wang, Y.; Lusis, A. J., Systems-based approaches to cardiovascular disease, Nat Rev Cardiol, 2012, 9 (3), 172-84.
Foster, W. H.; Tidball, J. G.; Wang, Y., p38gamma activity is required for maintenance of slow skeletal muscle size, Muscle Nerve, 2012, 45 (2), 266-73.
Hofmann, J. J.; Briot, A.; Enciso, J.; Zovein, A. C.; Ren, S.; Zhang, Z. W.; Radtke, F.; Simons, M.; Wang, Y.; Iruela-Arispe, M. L., Endothelial deletion of murine Jag1 leads to valve calcification and congenital heart defects associated with Alagille syndrome, Development, 2012, 139 (23), 4449-60.
Hajjar, R. J.; Leri, A.; Wang, Y., BCVS scientific conference 2012 meeting report, Circ Res, 2012, 111 (9), 1121-4.
Akki, A.; Su, J.; Yano, T.; Gupta, A.; Wang, Y.; Leppo, M. K.; Chacko, V. P.; Steenbergen, C.; Weiss, R. G., Creatine kinase overexpression improves ATP kinetics and contractile function in postischemic myocardium, Am J Physiol Heart Circ Physiol, 2012, 303 (7), H844-52.
Weiss, J. N.; Karma, A.; MacLellan, W. R.; Deng, M.; Rau, C. D.; Rees, C. M.; Wang, J.; Wisniewski, N.; Eskin, E.; Horvath, S.; Qu, Z.; Wang, Y.; Lusis, A. J., "Good enough solutions" and the genetics of complex diseases, Circ Res, 2012, 111 (4), 493-504.
Zhou, M.; Lu, G.; Gao, C.; Wang, Y.; Sun, H., Tissue-specific and nutrient regulation of the branched-chain alpha-keto acid dehydrogenase phosphatase, protein phosphatase 2Cm (PP2Cm), J Biol Chem, 2012, 287 (28), 23397-406.
Sun, H.; Wang, Y., Prostaglandin E2 in remote control of myocardial remodeling, Circulation, 2012, 125 (23), 2818-20.
Jeyaraj, D.; Scheer, F. A.; Ripperger, J. A.; Haldar, S. M.; Lu, Y.; Prosdocimo, D. A.; Eapen, S. J.; Eapen, B. L.; Cui, Y.; Mahabeleshwar, G. H.; Lee, H. G.; Smith, M. A.; Casadesus, G.; Mintz, E. M.; Sun, H.; Wang, Y.; Ramsey, K. M.; Bass, J.; Shea, S. A.; Albrecht, U.; Jain, M. K., Klf15 orchestrates circadian nitrogen homeostasis, Cell Metab, 2012, 15 (3), 311-23.
Ota, A.; Wang, Y., Cdc37/Hsp90 protein-mediated regulation of IRE1alpha protein activity in endoplasmic reticulum stress response and insulin synthesis in INS-1 cells, J Biol Chem, 2012, 287 (9), 6266-74.
Zhu, W.; Petrashevskaya, N.; Ren, S.; Zhao, A.; Chakir, K.; Gao, E.; Chuprun, J. K.; Wang, Y.; Talan, M.; Dorn, G. W., 2nd; Lakatta, E. G.; Koch, W. J.; Feldman, A. M.; Xiao, R. P., Gi-biased beta2AR signaling links GRK2 upregulation to heart failure, Circ Res, 2012, 110 (2), 265-74.
Gupta, A.; Akki, A.; Wang, Y.; Leppo, M. K.; Chacko, V. P.; Foster, D. B.; Caceres, V.; Shi, S.; Kirk, J. A.; Su, J.; Lai, S.; Paolocci, N.; Steenbergen, C.; Gerstenblith, G.; Weiss, R. G., Creatine kinase-mediated improvement of function in failing mouse hearts provides causal evidence the failing heart is energy starved, J Clin Invest, 2012, 122 (1), 291-302.
Sun, H.; Lu, G.; Ren, S.; Chen, J.; Wang, Y., Catabolism of branched-chain amino acids in heart failure: insights from genetic models, Pediatr Cardiol, 2011, 32 (3), 305-10.
Deng, N.; Zhang, J.; Zong, C.; Wang, Y.; Lu, H.; Yang, P.; Wang, W.; Young, G. W.; Wang, Y.; Korge, P.; Lotz, C.; Doran, P.; Liem, D. A.; Apweiler, R.; Weiss, J. N.; Duan, H.; Ping, P., Phosphoproteome analysis reveals regulatory sites in major pathways of cardiac mitochondria, Mol Cell Proteomics, 2011, 10 (2), M110 000117.
Marber, M. S.; Rose, B.; Wang, Y., The p38 mitogen-activated protein kinase pathway--a potential target for intervention in infarction, hypertrophy, and heart failure, J Mol Cell Cardiol, 2011, 51 (4), 485-90.
Lee, J. H.; Gao, C.; Peng, G.; Greer, C.; Ren, S.; Wang, Y.; Xiao, X., Analysis of transcriptome complexity through RNA sequencing in normal and failing murine hearts, Circ Res, 2011, 109 (12), 1332-41.
Korge, P.; Yang, L.; Yang, J. H.; Wang, Y.; Qu, Z.; Weiss, J. N., Protective role of transient pore openings in calcium handling by cardiac mitochondria, J Biol Chem, 2011, 286 (40), 34851-7.
Huang, Y.; Zhou, M.; Sun, H.; Wang, Y., Branched-chain amino acid metabolism in heart disease: an epiphenomenon or a real culprit?, Cardiovasc Res, 2011, 90 (2), 220-3.
Sun, H.; Wang, Y., Restriction of big hearts by a small RNA, Circ Res, 2011, 108 (3), 274-6.
Yang, S. H.; Chang, S. Y.; Ren, S.; Wang, Y.; Andres, D. A.; Spielmann, H. P.; Fong, L. G.; Young, S. G., Absence of progeria-like disease phenotypes in knock-in mice expressing a non-farnesylated version of progerin, Hum Mol Genet, 2011, 20 (3), 436-44.
Streicher, J. M.; Kamei, K.; Ishikawa, T. O.; Herschman, H.; Wang, Y., Compensatory hypertrophy induced by ventricular cardiomyocyte-specific COX-2 expression in mice, J Mol Cell Cardiol, 2010, 49 (1), 88-94.
Otsuka, M.; Kang, Y. J.; Ren, J.; Jiang, H.; Wang, Y.; Omata, M.; Han, J., Distinct effects of p38alpha deletion in myeloid lineage and gut epithelia in mouse models of inflammatory bowel disease, Gastroenterology, 2010, 138 (4), 1255-65, 1265 e1-9.
Rose, B. A.; Force, T.; Wang, Y., Mitogen-activated protein kinase signaling in the heart: angels versus demons in a heart-breaking tale, Physiol Rev, 2010, 90 (4), 1507-46.
Ahuja, P.; Zhao, P.; Angelis, E.; Ruan, H.; Korge, P.; Olson, A.; Wang, Y.; Jin, E. S.; Jeffrey, F. M.; Portman, M.; Maclellan, W. R., Myc controls transcriptional regulation of cardiac metabolism and mitochondrial biogenesis in response to pathological stress in mice, J Clin Invest, 2010, 120 (5), 1494-505.
Paulsson, A. K.; Franklin, S.; Mitchell-Jordan, S. A.; Ren, S.; Wang, Y.; Vondriska, T. M., Post-translational regulation of calsarcin-1 during pressure overload-induced cardiac hypertrophy, J Mol Cell Cardiol, 2010, 48 (6), 1206-14.
Papanicolaou, K. N.; Streicher, J. M.; Ishikawa, T. O.; Herschman, H.; Wang, Y.; Walsh, K., Preserved heart function and maintained response to cardiac stresses in a genetic model of cardiomyocyte-targeted deficiency of cyclooxygenase-2, J Mol Cell Cardiol, 2010, 49 (2), 196-209.
Liu, Z.; Fan, H. Y.; Wang, Y.; Richards, J. S., Targeted disruption of Mapk14 (p38MAPKalpha) in granulosa cells and cumulus cells causes cell-specific changes in gene expression profiles that rescue COC expansion and maintain fertility, Mol Endocrinol, 2010, 24 (9), 1794-804.
Zhang, M.; Takimoto, E.; Hsu, S.; Lee, D. I.; Nagayama, T.; Danner, T.; Koitabashi, N.; Barth, A. S.; Bedja, D.; Gabrielson, K. L.; Wang, Y.; Kass, D. A., Myocardial remodeling is controlled by myocyte-targeted gene regulation of phosphodiesterase type 5, J Am Coll Cardiol, 2010, 56 (24), 2021-30.
Fung, A. O.; Tsiokos, C.; Paydar, O.; Chen, L. H.; Jin, S.; Wang, Y.; Judy, J. W., Electrochemical properties and myocyte interaction of carbon nanotube microelectrodes, Nano Lett, 2010, 10 (11), 4321-7.
Drews, O.; Tsukamoto, O.; Liem, D.; Streicher, J.; Wang, Y.; Ping, P., Differential regulation of proteasome function in isoproterenol-induced cardiac hypertrophy, Circ Res, 2010, 107 (9), 1094-101.
Davies, B. S.; Barnes, R. H., 2nd; Tu, Y.; Ren, S.; Andres, D. A.; Spielmann, H. P.; Lammerding, J.; Wang, Y.; Young, S. G.; Fong, L. G., An accumulation of non-farnesylated prelamin A causes cardiomyopathy but not progeria, Hum Mol Genet, 2010, 19 (13), 2682-94.
Streicher, J. M.; Ren, S.; Herschman, H.; Wang, Y., MAPK-activated protein kinase-2 in cardiac hypertrophy and cyclooxygenase-2 regulation in heart, Circ Res, 2010, 106 (8), 1434-43.
Ota, A.; Zhang, J.; Ping, P.; Han, J.; Wang, Y., Specific regulation of noncanonical p38alpha activation by Hsp90-Cdc37 chaperone complex in cardiomyocyte, Circ Res, 2010, 106 (8), 1404-12.
Cross, H. R.; Li, M.; Petrich, B. G.; Murphy, E.; Wang, Y.; Steenbergen, C., Effect of p38 MAP kinases on contractility and ischemic injury in intact heart, Acta Physiol Hung, 2009, 96 (3), 307-23.
Lu, G.; Sun, H.; Korge, P.; Koehler, C. M.; Weiss, J. N.; Wang, Y., Functional characterization of a mitochondrial Ser/Thr protein phosphatase in cell death regulation, Methods Enzymol, 2009, 457, 255-73.
Ruan, H.; Li, J.; Ren, S.; Gao, J.; Li, G.; Kim, R.; Wu, H.; Wang, Y., Inducible and cardiac specific PTEN inactivation protects ischemia/reperfusion injury, J Mol Cell Cardiol, 2009, 46 (2), 193-200.
Seimon, T. A.; Wang, Y.; Han, S.; Senokuchi, T.; Schrijvers, D. M.; Kuriakose, G.; Tall, A. R.; Tabas, I. A., Macrophage deficiency of p38alpha MAPK promotes apoptosis and plaque necrosis in advanced atherosclerotic lesions in mice, J Clin Invest, 2009, 119 (4), 886-98.
Andersson, K. B.; Finsen, A. V.; Sjaland, C.; Winer, L. H.; Sjaastad, I.; Odegaard, A.; Louch, W. E.; Wang, Y.; Chen, J.; Chien, K. R.; Sejersted, O. M.; Christensen, G., Mice carrying a conditional Serca2(flox) allele for the generation of Ca(2+) handling-deficient mouse models, Cell Calcium, 2009, 46 (3), 219-25.
Andersson, K. B.; Birkeland, J. A.; Finsen, A. V.; Louch, W. E.; Sjaastad, I.; Wang, Y.; Chen, J.; Molkentin, J. D.; Chien, K. R.; Sejersted, O. M.; Christensen, G., Moderate heart dysfunction in mice with inducible cardiomyocyte-specific excision of the Serca2 gene, J Mol Cell Cardiol, 2009, 47 (2), 180-7.
Lu, G.; Sun, H.; She, P.; Youn, J. Y.; Warburton, S.; Ping, P.; Vondriska, T. M.; Cai, H.; Lynch, C. J.; Wang, Y., Protein phosphatase 2Cm is a critical regulator of branched-chain amino acid catabolism in mice and cultured cells, J Clin Invest, 2009, 119 (6), 1678-87.
Sun, Y.; Ishibashi, M.; Seimon, T.; Lee, M.; Sharma, S. M.; Fitzgerald, K. A.; Samokhin, A. O.; Wang, Y.; Sayers, S.; Aikawa, M.; Jerome, W. G.; Ostrowski, M. C.; Bromme, D.; Libby, P.; Tabas, I. A.; Welch, C. L.; Tall, A. R., Free cholesterol accumulation in macrophage membranes activates Toll-like receptors and p38 mitogen-activated protein kinase and induces cathepsin K, Circ Res, 2009, 104 (4), 455-65.
Lu, G.; Wang, Y., Functional diversity of mammalian type 2C protein phosphatase isoforms: new tales from an old family, Clin Exp Pharmacol Physiol, 2008, 35 (2), 107-12.
Streicher, J. M.; Wang, Y., The role of COX-2 in heart pathology, Cardiovasc Hematol Agents Med Chem, 2008, 6 (1), 69-79.
Nguyen, C. T.; Lu, Q.; Wang, Y.; Chen, J. N., Zebrafish as a model for cardiovascular development and disease, Drug Discov Today Dis Models, 2008, 5 (3), 135-140.
Mitchell-Jordan, S. A.; Holopainen, T.; Ren, S.; Wang, S.; Warburton, S.; Zhang, M. J.; Alitalo, K.; Wang, Y.; Vondriska, T. M., Loss of Bmx nonreceptor tyrosine kinase prevents pressure overload-induced cardiac hypertrophy, Circ Res, 2008, 103 (12), 1359-62.
Vondriska, T. M.; Wang, Y., A new (heat) shocking player in cardiac hypertrophy, Circ Res, 2008, 103 (11), 1194-6.
Kang, Y. J.; Chen, J.; Otsuka, M.; Mols, J.; Ren, S.; Wang, Y.; Han, J., Macrophage deletion of p38alpha partially impairs lipopolysaccharide-induced cellular activation, J Immunol, 2008, 180 (7), 5075-82.
Peter, P. S.; Brady, J. E.; Yan, L.; Chen, W.; Engelhardt, S.; Wang, Y.; Sadoshima, J.; Vatner, S. F.; Vatner, D. E., Inhibition of p38 alpha MAPK rescues cardiomyopathy induced by overexpressed beta 2-adrenergic receptor, but not beta 1-adrenergic receptor, J Clin Invest, 2007, 117 (5), 1335-43.
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