California NanoSystems Institute
CNSI
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Kathleen Kelly, Ph.D.

   
Professor, Pathology and Laboratory Medicine
Member, California NanoSystems Institute

Education:
Degrees:
Ph.D., Ohio State University, 1990
B.S., Ohio State University, 1983

Honors and Awards:
2003 Association of Clinical Scientists, Young Clinical Scientist Award
2000 College of Medicine, UCLA, Frontiers in Science Award
1994 Academy of Clinical Laboratory Physicians and Scientists Young Investigator Award
1992 Academy of Clinical Laboratory Physicians and Scientists Young Investigator Award
1986 - 1990 Department of Medical Microbiology & Immunology, Ohio State University, Graduate Research Award

Academic Experience:
Academic Experience:
1996 Univ. of Arkansas for Med. Sci., Reproductive Immunology
1990 - 1995 Washington University, Immunology

Contact Information:
Email Address: kkelly@mednet.ucla.edu
Laboratory Address: Laboratory
Department of Pathology & Lab. Medicine
Mailroom A7-142 CHS
mailcode 173216
Los Angeles, CA 90095
UNITED STATES
Work Address: Office
Department of Pathology & Lab Medicine
Mailroom A7-149 CHS
mailcode 173216
Los Angeles, CA 90095
UNITED STATES
Home Page: http://faculty.pathology.ucla.edu/institution/personnel?personnel_id=45971
Work Phone Number: (310) 206-4910 Laboratory
310-206-5562 Office
Research Interests:

Immunity at Mucosal Surfaces
The ability of the immune system to protect mucosal surfaces against invasion by pathogens is a poorly understood process. Mucosal surfaces are continually exposed to the outside environment but unlike the skin, have other functions such as adsorbing nutrients, exchanging gases or supporting reproduction. However, if an immune response proceeds unchecked, chronic inflammation develops which leads to pathologic reactions and disrupted tissue function. The focus of our lab is to understand how host immune responses are induced and regulated within mucosal sites. As a model system we study infections caused by the obligate intracellular bacteria Chlamydia trachomatis. Chlamydial organisms dwell in mucosal epithelial cells and often persist despite the production of immunity. Chronic chlamydial infections are an important cause of pelvic inflammatory disease, ectopic pregnancy, and infertility in women and have also been linked with arthritis and atherosclerosis. Dendritic cells and Th1 CD4 T cells that produce IFN-gamma are important for developing protective immunity against Chlamydia infections and our studies are focused on these cell types. Specifically, we are investigating how the route of immunization (mucosal vs. parenteral) influences the development of a protective immune response, the role of dendritic cells in protective immunity and whether T-regulatory CD4 cells are important for controlling or interfering with Th1 responses against Chlamydia. Our overall goal is to contribute to the production of a protective vaccine and/or therapeutic intervention against tissue pathology induced by chronic infections.


Additional Information:

Kathleen Kelly is an Associate Professor who joined the Department of Pathlogy and Lab Medicine in 1999. Dr. Kelly earned her B.S. in Medical Technology and PhD in Immunology at the Ohio State University in Columbus, Ohio. She was a postdoctoral fellow at Washington University in St. Louis, where she worked on the role of T cell subsets in germinal center formation. She then served as a junior faculty member in the Department of Microbiology and Immunology at the Unviersity of Arkansas for Medical Sciences. She focused on mucosal immunology and concentrated her studies on immune responses in the reproductive tract. Dr. Kelly is actively involved in graduate, undergraduate and medical student education. She is a recipient of the Young Scientist Award and past chair of the Immunology Division for the American Society of Microbiology.

Selected Publications:

Moniz, R.J. Chan, A.M., Gordon, L.K., Braun, J., Arditi, M., Kelly, K.A., Plasmacytoid dendritic cells modulate non-protective T cell responses to genital infection by C. muridarum, FEMS Immunol Med Microbiol, 2010, 58 (3), 397-404.
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Champion Cheryl I, Kickhoefer Valerie A, Liu Guangchao, Moniz Raymond J, Freed Amanda S, Bergmann Liisa L, Vaccari Dana, Raval-Fernandes Sujna, Chan Ann M, Rome Leonard H, Kelly Kathleen A, A vault nanoparticle vaccine induces protective mucosal immunity, PloS one, 2009, 4 (4), e5409.
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Shimazaki Kaori, Chan Ann M, Moniz Raymond J, Wadehra Madhuri, Nagy Agnes, Coulam Catherine P, Mareninov Sergey, Lepin Eric M, Wu Anna M, Kelly Kathleen A, Braun Jonathan, Gordon Lynn K, Blockade of epithelial membrane protein 2 (EMP2) abrogates infection of Chlamydia muridarum murine genital infection model, FEMS immunology and medical microbiology, 2009, 55 (2), 240-9.
King M, Poya H, Rao J, Natarajan S, Butch AW, Aziz N, Kok S, Chang MH, Lyons JM, Ault K, Kelly KA, CXCL13 expression in Chlamydia trachomatis infection of the female reproductive tract, Drugs Today (Barc), 2009, 45 (Supplement B), 125-34.
Moniz Raymond J, Chan Ann M, Kelly Kathleen A, Identification of dendritic cell subsets responding to genital infection by Chlamydia muridarum, FEMS immunology and medical microbiology, 2009, 55 (2), 226-36.
Abdul-Sater, A.A., Saïd-Sadier, N., Ojcius, D.M., Yimaz, Ö, Yimaz and Kelly, K.A., Infammasomes Bridge Signaling Between Pathogen Identification and the Immune Response, Drugs of Today, 2009, 45, 96-104.
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Kickhoefer Valerie A, Han Muri, Raval-Fernandes Sujna, Poderycki Michael J, Moniz Raymond J, Vaccari Dana, Silvestry Mariena, Stewart Phoebe L, Kelly Kathleen A, Rome Leonard H, Targeting vault nanoparticles to specific cell surface receptors, ACS nano, 2009, 3 (1), 27-36.
Kelly, Wiley, Wiesmeier, Briskin, Butch, Darville, The Combination of the Gastrointestinal Integrin (alpha4beta7) and Selectin Ligand Enhances T-Cell Migration to the Reproductive Tract During Infection with Chlamydia trachomatis, American journal of reproductive immunology, 2009, Epub ahead of print.
Kelly KA, Wiley, D, Butch, A, Wiesmeier, E, Briskin, M and Darville, T. , The combination of α4β7 and selectin ligand enhances T cell migration to the reproductive tract during bacterial infection. , Am J Reprod Immunol, 2009, 6, 446-452.
Kelly, KA, Chan, A.M., Butch, A.W. and Darville, T. , Two different homing pathways involving integrin β7 and E-selectin significantly influence trafficking of CD4 cells to the genital tract following C. muridarum infection. , Am J Reprod Immunol, 2009, 61 (6), 438-445.
Kaori Shimazaki, Ann M. Chan, Raymond J. Moniz, Eric M. Lepin, Agnes Nagy, Paige Coulum, Sergey Mareninov, James D. Marks, Anna M. Wu, Kathleen A. Kelly, Jonathan Braun and Lynn K. Gordon., Blockade of epithelial membrane protein 2 (EMP2) abrogates infection of Chlamydia muridarum (MoPn) murine genital infection model, FEMS Immunol Med Microbiol, 2008, 1574-695X.
Raymond J. Moniz, Chan, A.M. and Kelly, K., Identification of dendritic cell subsets responding to genital infection by Chlamydia trachomatis, FEMS Immunol Med Microbiol, 2008, 1574-695X.
Liu, W. Kelly, K. A., Prostaglandin E2 modulates dendritic cell function during chlamydial genital infection, Immunology, 2008, 123 (2), 290-303.
Kelly Kathleen A, Butch Anthony W, Antigen-specific immunoglobulin E+ B cells are preferentially localized within germinal centres, Immunology, 2007, 120 (3), 345-53.
Kaori, S. Wadehra, M, Forbes, A., Kelly, K.A., Goodglick, L., Braun, J. and Gordo, L.K. , Epithelial membrane protein 2 modulates infectivity of Chlamydia muridarum (MoPn), Microbes Infect, 2007, 9, 1003-1010.
Liu, W. and Kelly, K.A., Postaglandin E2 modulates dendritic cell function during chlamydial genital infection. , Immunology, 2007, 123, 1365-2567.
Liu, W. Dubinett, S. Patterson, S. L. Kelly, K. A., COX-2 inhibition affects growth rate of Chlamydia muridarum within epithelial cells, Microbes Infect, 2006, 8 (2), 478-86.
Kelly, K.A., Chapter 19:T lymphocyte trafficking to the female reproductive mucosae, In Chlamydia: Genomics, Pathogenesis and Implications for Control. Horizon Scientific Press, Norwick, UK, 2006, 413-433.
Kelly K.A. and Butch, A.W., Localization of antigen-specific IgE+ cells within germinal centers in a primary immune response to 2-phenyloxazolone, Immunology, 2006, 120, 346-353.
Welter-Stahl, L, Ojcius, D.M. Viala, J. Girardin, S. Liu, W, Delarbre, C. Philpott, D. Kelly, K.A. Darville, T. , Stimulation of the cytosolic receptor for peptidoglycan, Nod1, by infection with Chlamydia trachomatis or Chlamydia muridarum, Cell Microbiol, 2006, 8, 1047-57.
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Maxion, H. K. Liu, W. Chang, M. H. Kelly, K. A., The infecting dose of Chlamydia muridarum modulates the innate immune response and ascending infection, Infect Immun, 2004, 72 (11), 6330-40.
Kelly, K. A., Cellular immunity and Chlamydia genital infection: induction, recruitment, and effector mechanisms, Int Rev Immunol, 2003, 22 (1), 3-41.
Hawkins, R.A., Rank, R.G. and Kelly, K.A, A Chlamydia-specific Th2 clone induces antibody production but not protection against a genital infection, Infection and Immunity, 2002, 70, 5132-5139.
Maxion, H. K. Kelly, K. A., Chemokine expression patterns differ within anatomically distinct regions of the genital tract during Chlamydia trachomatis infection, Infect Immun, 2002, 70 (3), 1538-46.
Ault, KA Kelly, KA Ruther, PE Izzo, AA Izzo, LS Sigar, IM Ramsey, KH, Chlamydia trachomatis enhances the expression of matrix metalloproteinases in an in vitro model of the human fallopian tube infection, American journal of obstetrics and gynecology. , 2002, 187 (5), 1377-83.
Maxion, H.K. and Kelly, K.A, Differential chemokine expression in distinct regions of the murine gential tract in response to infection with Chlamydia trachomatis, Infection and Immunity, 2002, 70, 1538-1546.
Jiang Janina, Kelly Kathleen A, Phenotype and function of regulatory T cells in the genital tract, Current trends in immunology, 2011, 12 (1), 89-94.
Kar Upendra K, Jiang Janina, Champion Cheryl I, Salehi Sahar, Srivastava Minu, Sharma Sherven, Rabizadeh Shahrooz, Niazi Kayvan, Kickhoefer Valerie, Rome Leonard H, Kelly Kathleen A, Vault Nanocapsules as Adjuvants Favor Cell-Mediated over Antibody-Mediated Immune Responses following Immunization of Mice, PloS one, 2012, 7 (7), e38553.