California NanoSystems Institute
CNSI
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Alexander Spokoyny, Ph.D.

   
Professor, Chemistry and Biochemistry
Member, California NanoSystems Institute

Education:
Degrees:
Ph.D.

Contact Information:
Email Address: spokoyny@chem.ucla.edu
Laboratory Address: Molecular Sciences 1230
CA
UNITED STATES
Office Address: Molecular Sciences 1505
CA
UNITED STATES
Additional Information:

Dr. Alexander Spokoyny was born and spent his childhood and teenage years in Moscow, Russia. After his family immigrated to United States in 2001, Alex attended UCLA, where he was introduced to the area of boron cluster chemistry working as an undergraduate researcher in the laboratory of Prof. M. Frederick Hawthorne. He continued his graduate chemistry education at Northwestern University under the guidance of Prof. Chad A. Mirkin. At Northwestern, Alex developed new materials, devices, and fundamentally new classes of ligand platforms based on organomimetic carborane clusters. Upon receiving his Ph.D. in inorganic chemistry in 2011, Alex decided to move further east, where he was an NIH Post-Doctoral Fellow working in the laboratories of Profs. Stephen L. Buchwald and Bradley L. Pentelute at MIT. There his research interests involved the development of new bioconjugation strategies for peptides and proteins and regulation of protein-protein interactions.

Selected Publications:

Axtell Jonathan C, Kirlikovali Kent O, Djurovich Peter I, Jung Dahee, Nguyen Vinh T, Munekiyo Brian, Royappa A Timothy, Rheingold Arnold L, Spokoyny Alexander M, Blue Phosphorescent Zwitterionic Iridium(III) Complexes Featuring Weakly Coordinating nido-Carborane-Based Ligands, Journal of the American Chemical Society, 2016, 138 (48), 15758-15765.
Saleh Liban M A, Dziedzic Rafal, Spokoyny Alexander M, An Inorganic Twist in Nanomaterials: Making an Atomically Precise Double Helix, ACS central science, 2016, 2 (10), 685-686.
Dziedzic Rafal M, Saleh Liban M A, Axtell Jonathan C, Martin Joshua L, Stevens Simone L, Royappa A Timothy, Rheingold Arnold L, Spokoyny Alexander M, B-N, B-O, and B-CN Bond Formation via Palladium-Catalyzed Cross-Coupling of B-Bromo-Carboranes, Journal of the American Chemical Society, 2016, 138 (29), 9081-4.
Saleh Liban M A, Dziedzic Rafal M, Khan Saeed I, Spokoyny Alexander M, Forging Unsupported Metal-Boryl Bonds with Icosahedral Carboranes, Chemistry (Weinheim an der Bergstrasse, Germany), 2016, 22 (25), 8466-70.
Messina Marco S, Axtell Jonathan C, Wang Yiqun, Chong Paul, Wixtrom Alex I, Kirlikovali Kent O, Upton Brianna M, Hunter Bryan M, Shafaat Oliver S, Khan Saeed I, Winkler Jay R, Gray Harry B, Alexandrova Anastassia N, Maynard Heather D, Spokoyny Alexander M, Visible-Light-Induced Olefin Activation Using 3D Aromatic Boron-Rich Cluster Photooxidants, Journal of the American Chemical Society, 2016, 138 (22), 6952-5.
Wixtrom Alex I, Shao Yanwu, Jung Dahee, Machan Charles W, Kevork Shaunt N, Qian Elaine A, Axtell Jonathan C, Khan Saeed I, Kubiak Clifford P, Spokoyny Alexander M, Rapid Synthesis of Redox-Active Dodecaborane B12(OR)12 Clusters Under Ambient Conditions, Inorganic chemistry frontiers, 2016, 3 (5), 711-717.
Schwartz Jeffrey J, Mendoza Alexandra M, Wattanatorn Natcha, Zhao Yuxi, Nguyen Vinh T, Spokoyny Alexander M, Mirkin Chad A, Baše Tomáš, Weiss Paul S, Surface Dipole Control of Liquid Crystal Alignment, Journal of the American Chemical Society, 2016, 138 (18), 5957-67.
Vinogradova Ekaterina V, Zhang Chi, Spokoyny Alexander M, Pentelute Bradley L, Buchwald Stephen L, Organometallic palladium reagents for cysteine bioconjugation, Nature, 2015, 526 (7575), 687-91.
Thomas John C, Schwartz Jeffrey J, Hohman J Nathan, Claridge Shelley A, Auluck Harsharn S, Serino Andrew C, Spokoyny Alexander M, Tran Giang, Kelly Kevin F, Mirkin Chad A, Gilles Jerome, Osher Stanley J, Weiss Paul S, Defect-Tolerant Aligned Dipoles within Two-Dimensional Plastic Lattices, ACS nano, 2015, 9 (5), 4734-42.
Zhang Chi, Dai Peng, Spokoyny Alexander M, Pentelute Bradley L, Enzyme-catalyzed macrocyclization of long unprotected peptides, Organic letters, 2014, 16 (14), 3652-5.
Simon Mark D, Heider Patrick L, Adamo Andrea, Vinogradov Alexander A, Mong Surin K, Li Xiyuan, Berger Tatiana, Policarpo Rocco L, Zhang Chi, Zou Yekui, Liao Xiaoli, Spokoyny Alexander M, Jensen Klavs F, Pentelute Bradley L, Rapid flow-based peptide synthesis, Chembiochem : a European journal of chemical biology, 2014, 15 (5), 713-20.
Zou Yekui, Spokoyny Alexander M, Zhang Chi, Simon Mark D, Yu Hongtao, Lin Yu-Shan, Pentelute Bradley L, Convergent diversity-oriented side-chain macrocyclization scan for unprotected polypeptides, Organic & biomolecular chemistry, 2014, 12 (4), 566-73.
Zhang Chi, Spokoyny Alexander M, Zou Yekui, Simon Mark D, Pentelute Bradley L, Enzymatic "click" ligation: selective cysteine modification in polypeptides enabled by promiscuous glutathione S-transferase, Angewandte Chemie (International ed. in English), 2013, 52 (52), 14001-5.
Lifschitz Alejo M, Shade Chad M, Spokoyny Alexander M, Mendez-Arroyo Jose, Stern Charlotte L, Sarjeant Amy A, Mirkin Chad A, Boron-dipyrromethene-functionalized hemilabile ligands as "turn-on" fluorescent probes for coordination changes in weak-link approach complexes, Inorganic chemistry, 2013, 52 (9), 5484-92.
Spokoyny Alexander M, New ligand platforms featuring boron-rich clusters as organomimetic substituents(.), Pure and applied chemistry. Chimie pure et appliquee, 2013, 85 (5), 5484-92.
Spokoyny Alexander M, Zou Yekui, Ling Jingjing J, Yu Hongtao, Lin Yu-Shan, Pentelute Bradley L, A perfluoroaryl-cysteine S(N)Ar chemistry approach to unprotected peptide stapling, Journal of the American Chemical Society, 2013, 135 (16), 5946-9.
Spokoyny Alexander M, Lewis Calvin D, Teverovskiy Georgiy, Buchwald Stephen L, Extremely Electron-Rich, Boron-Functionalized, Icosahedral Carborane-Based Phosphinoboranes, Organometallics, 2012, 31 (24), 8478-8481.
Spokoyny Alexander M, Machan Charles W, Clingerman Daniel J, Rosen Mari S, Wiester Michael J, Kennedy Robert D, Stern Charlotte L, Sarjeant Amy A, Mirkin Chad A, A coordination chemistry dichotomy for icosahedral carborane-based ligands, Nature chemistry, 2011, 3 (8), 590-6.
Machan Charles W, Spokoyny Alexander M, Jones Matthew R, Sarjeant Amy A, Stern Charlotte L, Mirkin Chad A, Plasticity of the nickel(II) coordination environment in complexes with hemilabile phosphino thioether ligands, Journal of the American Chemical Society, 2011, 133 (9), 3023-33.
Rosen Mari S, Spokoyny Alexander M, Machan Charles W, Stern Charlotte, Sarjeant Amy, Mirkin Chad A, Chelating effect as a driving force for the selective formation of heteroligated Pt(II) complexes with bidentate phosphino-chalcoether ligands, Inorganic chemistry, 2011, 50 (4), 1411-9.
Spokoyny Alexander M, Li Tina C, Farha Omar K, Machan Charles W, She Chunxing, Stern Charlotte L, Marks Tobin J, Hupp Joseph T, Mirkin Chad A, Electronic tuning of nickel-based bis(dicarbollide) redox shuttles in dye-sensitized solar cells, Angewandte Chemie (International ed. in English), 2010, 49 (31), 5339-43.
Bae Youn-Sang, Spokoyny Alexander M, Farha Omar K, Snurr Randall Q, Hupp Joseph T, Mirkin Chad A, Separation of gas mixtures using Co(II) carborane-based porous coordination polymers, Chemical communications (Cambridge, England), 2010, 46 (20), 3478-80.
Li Tina C, Spokoyny Alexander M, She Chunxing, Farha Omar K, Mirkin Chad A, Marks Tobin J, Hupp Joseph T, Ni(III)/(IV) bis(dicarbollide) as a fast, noncorrosive redox shuttle for dye-sensitized solar cells, Journal of the American Chemical Society, 2010, 132 (13), 4580-2.
Farha Omar K, Bae Youn-Sang, Hauser Brad G, Spokoyny Alexander M, Snurr Randall Q, Mirkin Chad A, Hupp Joseph T, Chemical reduction of a diimide based porous polymer for selective uptake of carbon dioxide versus methane, Chemical communications (Cambridge, England), 2010, 46 (7), 1056-8.
Spokoyny Alexander M, Rosen Mari S, Ulmann Pirmin A, Stern Charlotte, Mirkin Chad A, Selective formation of heteroligated Pt(II) complexes with bidentate phosphine-thioether (P,S) and phosphine-Selenoether (P,Se) ligands via the halide-induced ligand rearrangement reaction, Inorganic chemistry, 2010, 49 (4), 1577-86.
Farha Omar K, Spokoyny Alexander M, Mulfort Karen L, Galli Simona, Hupp Joseph T, Mirkin Chad A, Gas-sorption properties of cobalt(II)--carborane-based coordination polymers as a function of morphology, Small (Weinheim an der Bergstrasse, Germany), 2009, 5 (15), 1727-31.
Spokoyny Alexander M, Reuter Matthew G, Stern Charlotte L, Ratner Mark A, Seideman Tamar, Mirkin Chad A, Carborane-based pincers: synthesis and structure of SeBSe and SBS Pd(II) complexes, Journal of the American Chemical Society, 2009, 131 (27), 9482-3.
Spokoyny Alexander M, Kim Dongwoo, Sumrein Abdelqader, Mirkin Chad A, Infinite coordination polymer nano- and microparticle structures, Chemical Society reviews, 2009, 38 (5), 1218-27.
Bae Youn-Sang, Farha Omar K, Spokoyny Alexander M, Mirkin Chad A, Hupp Joseph T, Snurr Randall Q, Carborane-based metal-organic frameworks as highly selective sorbents for CO(2) over methane, Chemical communications (Cambridge, England), 2008, 38 (35), 4135-7.
Farha Omar K, Spokoyny Alexander M, Mulfort Karen L, Hawthorne M Frederick, Mirkin Chad A, Hupp Joseph T, Synthesis and hydrogen sorption properties of carborane based metal-organic framework materials, Journal of the American Chemical Society, 2007, 129 (42), 12680-1.