California NanoSystems Institute
CNSI
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Christopher Denny, M.D.

   
Professor, Pediatrics

Education:
Degrees:
M.D., University of Pennsylvania, Philadelphia, PA, 1976 - 1980
B.S., University of Pennsylvania, Philadelphia, PA, 1972 - 1976

Certifications:
Certifications:
1990 American Board of Pediatrics
1986 American Board of Pediatrics

Education:
Fellowship:
1983 - 1987 National Institutes of Health, The Clinical Center
Internship:
1980 - 1981 Children's Hospital National Medical Center
Residency:
1981 - 1983 Children's Hospital National Medical Center

Contact Information:
Work Email Address: cdenny@ucla.edu
Laboratory Address: Lab Address
700 Westwood Blvd
Los Angeles, CA 90095
UNITED STATES
Office Address: Office
10-240
CAMPUS - 175217
CA
UNITED STATES
Home Page: http://www.cancer.ucla.edu/index.aspx?page=645&recordid=67
Physician Profile: http://www.uclahealth.org/ChristopherDenny
Work Phone Number: (310) 825-0704 Office
Research Interests:

Dr. Christopher Denny's research focuses on genomic mutation as a primary force in the genesis of human malignancy. Molecular isolation of genes involved in tumor-specific rearrangements has identified mechanisms of tumorigenesis and has formed a basis for studying transformation pathways of human cancers.


Technical Research Interest:

The vast majority of systemic anticancer therapy does not specifically target tumor cells. Bystander effects on normal cells are primarily responsible for the significant toxicities encountered with most cytotoxic chemotherapies. Attempts to develop targeted therapies using immunoconjugates have been impeded by the finding that tumor-associated markers are also found on normal cells. A strategy that would simultaneously target more than one tumor-associated marker (multi-specific targeting) could improve specificity significantly. Tumor antigens are typically present in rare normal cell populations. Therefore the chances that two tumor-associated markers would both be present on a normal cell, would be much reduced. To explore this strategy, multi-specific nanoparticles will be constructed and tested in a tissue culture based model system. Binding of mono- and multispecific nanoparticles to indicator cell lines will be assessed. The ability of programmed nanoparticles containing cytotoxic agents to selectively kill marked tumor cells will be determined in mixed co-culture assays.



Selected Publications:

Anderson Jennifer L, Park Ann, Akiyama Ryan, Tap William D, Denny Christopher T, Federman Noah, Evaluation of In Vitro Activity of the Class I PI3K Inhibitor Buparlisib (BKM120) in Pediatric Bone and Soft Tissue Sarcomas, PloS one, 2015, 10 (9), e0133610.
Anderson Jennifer L, Titz Björn, Akiyama Ryan, Komisopoulou Evangelia, Park Ann, Tap William D, Graeber Thomas G, Denny Christopher T, Phosphoproteomic profiling reveals IL6-mediated paracrine signaling within the Ewing sarcoma family of tumors, Molecular cancer research : MCR, 2014, 12 (12), 1740-54.
Denny Christopher T, ChIP-ping away at EWS/ETS transcription networks, Cancer cell, 2014, 26 (5), 595-6.
Federman Noah, Chan Jason, Nagy Jon O, Landaw Elliot M, McCabe Katelyn, Wu Anna M, Triche Timothy, Kang Hyunggyoo, Liu Bin, Marks James D, Denny Christopher T, Enhanced growth inhibition of osteosarcoma by cytotoxic polymerized liposomal nanoparticles targeting the alcam cell surface receptor, Sarcoma, 2012, 2012, 126906.
Anderson Jennifer L, Denny Christopher T, Tap William D, Federman Noah, Pediatric Sarcomas: Translating Molecular Pathogenesis of Disease to Novel Therapeutic Possibilities, Pediatric research, 2012.
France Kelly A, Anderson Jennifer L, Park Ann, Denny Christopher T, Oncogenic fusion protein EWS/FLI1 down-regulates gene expression by both transcriptional and posttranscriptional mechanisms, The Journal of biological chemistry, 2011, 286 (26), 22750-7.
Federman Noah, Denny Christopher T, Targeting liposomes toward novel pediatric anticancer therapeutics, Pediatric research, 2010, 67 (5), 514-9.
Ikeda Alan K, Judelson Dejah R, Federman Noah, Glaser Keith B, Landaw Elliot M, Denny Christopher T, Sakamoto Kathleen M, ABT-869 inhibits the proliferation of Ewing Sarcoma cells and suppresses platelet-derived growth factor receptor beta and c-KIT signaling pathways, Molecular cancer therapeutics, 2010, 9 (3), 653-60.
Potikyan Gary, France Kelly A, Carlson Marc R J, Dong Jun, Nelson Stanley F, Denny Christopher T, Genetically defined EWS/FLI1 model system suggests mesenchymal origin of Ewing's family tumors, Laboratory investigation; a journal of technical methods and pathology, 2008, 88 (12), 1291-302.
Hicks Christopher M, Bandiera Glen W, Denny Christopher J, Building a simulation-based crisis resource management course for emergency medicine, phase 1: Results from an interdisciplinary needs assessment survey, Academic emergency medicine : official journal of the Society for Academic Emergency Medicine, 2008, 15 (11), 1136-43.
Potikyan Gary, Savene Rupert O V, Gaulden Julie M, France Kelly A, Zhou Zhichao, Kleinerman Eugenie S, Lessnick Stephen L, Denny Christopher T, EWS/FLI1 regulates tumor angiogenesis in Ewing's sarcoma via suppression of thrombospondins, Cancer research, 2007, 67 (14), 6675-84.
Ng King Pan, Potikyan Gary, Savene Rupert OV, Denny Christopher T, Uversky Vladimir N, Lee Kevin AW, Multiple aromatic side chains within a disordered structure are critical for transcription and transforming activity of EWS family oncoproteins, Proc. Natl. Acad. Sci. U.S.A, 2007, 104 (2), 479-84.
Davis Ian J, Kim Jessica J, Ozsolak Fatih, Widlund Hans R, Rozenblatt-Rosen Orit, Granter Scott R, Du Jinyan, Fletcher Jonathan A, Denny Christopher T, Lessnick Stephen L, Linehan W Marston, Kung Andrew L, Fisher David E, Oncogenic MITF dysregulation in clear cell sarcoma: defining the MiT family of human cancers, Cancer cell, 2006, 9 (6), 473-84.
Kim Sungeun, Denny Christopher T, Wisdom Ron, Cooperative DNA binding with AP-1 proteins is required for transformation by EWS-Ets fusion proteins, Molecular and cellular biology, 2006, 26 (7), 2467-78.
Deneen Benjamin, Hamidi Habib, Denny Christopher T, Functional analysis of the EWS/ETS target gene uridine phosphorylase, Cancer research, 2003, 63 (14), 4268-74.
Denny Christopher J, Steinhart Brian D, Yu Richard, Improving physician flow and efficiency in the emergency department, CJEM, 2003, 5 (4), 271-4.
Ho, T. Deneen, B. Denny, C. , Up-regulation of PIM3 may be necessary but not sufficient in the formation of tumors with the characteristics of Ewing's sarcoma family tumors, Journal of Investigative Medicine, 2003, 51, S100-S100.
Deneen Benjamin, Welford Scott M, Ho Thu, Hernandez Felicia, Kurland Irwin, Denny Christopher T, PIM3 proto-oncogene kinase is a common transcriptional target of divergent EWS/ETS oncoproteins, Molecular and cellular biology, 2003, 23 (11), 3897-908.
Maris John M, Denny Christopher T, Focus on embryonal malignancies, Cancer cell, 2002, 2 (6), 447-50.
Morra, M. Lu, J. Poy, F. Calpe, S. Martin, M. Gullo, C. Howie, D. Denny, C. Engel, P. Eck, M. J. Terhorst, C., The "free SH2-domain" EAT-2 binds CD150-related receptors in hematopoietic cells, Faseb Journal, 2002, 16 (4), A321-A321.
Foote Simon, Denny Christopher, Construction of YAC libraries with large inserts, Current protocols in human genetics / editorial board, Jonathan L. Haines ... [et al.], 2002, Chapter 5 (4), Unit5.2.
Deneen B, Denny CT, Loss of p16 pathways stabilizes EWS/FLI1 expression and complements EWS/FLI1 mediated transformation, Oncogene, 2001, 20 (46), 6731-41.
Denny, C., Defining small round cell tumors of childhood: When is a rose really a rose, Journal of Pediatric Hematology Oncology, 2001, 23 (6), 338-339.
Arvand A, Welford S, Teitell MA, Denny CT, The C-terminal domain of FLI-1 is necesary for full tumorigenic potential of the EWS/FLI1, Cancer Research, 2001, 61, 5311-17.
Welford SM, Gregg J, Chen E, Garrison D, Sorensen PH, Denny CT, Nelson SF, Detection of differentially expressed genes in primary tumor tissues using representational differences analysis coupled to microarray hybridization, Nucleic acids research, 1998, 26 (12), 3059-65.
May WA, Arvand A, Thompson AD, Braun BS, Wright M, Denny CT, EWS/FLI1-induced Manic Fringe renders NIH 3T3 cells tumorigenic, Nature Genetics, 1997, 17, 495-498.