California NanoSystems Institute
CNSI
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Andre Nel, M.B.Ch.B., Ph.D.

   
Division Chief, NanoMedicine
Professor, Department of Medicine
Director and PI, NSF/EPA-funded Center for Environmental Implications of Nanotechnology , California NanoSystems Institute
Member, California NanoSystems Institute, NanoBiotechnology and Biomaterials

Education:
Degrees:
M.B.Ch.B., University of Stellenbosch, Capetown, R.S.A, 1975
Ph.D., University Stellenbosch, 1987

Certifications:
Certifications:
1991 American Board of Allergy and Immunology
1989 American Board of Internal Medicine

Honors and Awards:
2012 - Speaker, The President Harry S. Truman Distinguished Award , Sandia National Laboratories, Albuquerque, New Mexico
2011 - Co-Chair, Nanotechnology Environmental Health and Safety (EHS) in the U.S. Science and Technology Working Group visit to Moscow, Russia. Group chaired by U.S. Director of the Office of Science and Technology Policy, John Holdren, and Russian Minister of Education and Science Technology, Andrey Fursenko, under the U.S.-Russia Bilateral Presidential Commission.
2010 - Co-Chair, US-Russia Nanotechnology Experts Meeting at the US State Dept (George Marshall Conference Center). This meeting was conducted under the U.S.-Russia Bilateral Presidential Commission., National Nanotechnology Initiative (NNI)
2010 - Co-chair, US-Russia Nanotechnology Experts Meeting at the US State Dept (George Marshall Conference Center) on This meeting was conducted under the U.S.-Russia Bilateral Presidential Commission, National Nanotechnology Initiative (NNI)
2010 - Invited participant, PCAST panel for the review of the NNI, National Nanotechnology Initiative (NNI)
2008 - 2010 Thompson Reuters Science Watch, Currents Classics nomination for 2006 Science paper (“Toxic potential of materials at the nanolevel”) on two separate occasions in the categories Multidisciplinary Science (2008) and Pharmacology and Toxicology (2010).
1998 - 2012 Peer selected inclusion, Best Doctors in America

Academic Experience:
Academic Experience:
2010 - 2015 Director, NIEHS-funded Center for NanoBiology and Predictive Toxicology
2009 - 2013 Chinese Academy of Science Distinguished Visiting Professorship and Honorary Member, Chinese Academy of Science, Beijing
2006 - 2013 Founder/Director, UC Lead Campus NanoToxicology Research Training Program

Contact Information:
Work Email Address: anel@mednet.ucla.edu
Mailing Address: Mail Code: 173617
Los Angeles, CA 90095
UNITED STATES
Office Address: UCLA Med-NanoMedicine
10833 Le Conte Ave.
52-175 CHS
Los Angeles, CA 90095
UNITED STATES
Home Page: http://www.cnsi.ucla.edu/institution/personnel?personnel%5fid=8739
Work: http://www.cein.ucla.edu
Work: http://www.uclahealth.org/AndreNel
Work Phone Number: (310) 825-6011 Clinic
(310) 825-6620 Work
(310) 825-3718 Office
(310) 206-8107 Fax
Research Interests:

Dr. Nel's chief research interests are: (i) Nanomedicine and Nanobiology, including nanomaterial therapeutic devices and the study of nanomaterial properties that lead to biocompatible and biohazardous interactions in humans and the environment; (ii) The role of air pollutants in asthma, with particular emphasis on the role of ultrafine particle-induced oxidative stress in the generation of airway inflammation and asthma. The research is funded by personal RO1 grants from the NIH, the NIAID-funded Asthma and Immunology Disease Clinical Research Center, an EPA STAR award, a $24 million NSF award for a NSF Science Engineering Center. Dr Nel is Director of the UC Center for the Environmental Impact of Nanotechnology (CEIN), Director of the UCLA Asthma and Immunology Disease Center, Co-Director of the Southern California Particle Center, and Co-Director of the UCLA Nanomachine Center. The Nanomachine Center (four co-PI?s) develops and utilizes smart nanoparticle delivery systems that can target and control drug release at cancer and disease sites. The mission of the multi-campus UC CEIN is to develop an early warning system for nanomaterial hazards and safe design, particularly as it relates to interactions with biological systems and ecological life forms.


Technical Research Interest:

Dr. Nel's chief research interests are:

(i) Nano-biology with particular interest in discovery of interfacial nanomaterial properties that can be used to improve biosafety, improved design of nanotherapeutics and establishing quantitative structure-activity relationships;

(ii) Nanomedicine and nanotherapeutics with particular emphasis on the development of a nanoparticle treatment platform that can be used for drug delivery, siRNA delivery and imaging;

(iii) Nano EHS, with particular interest in developing predictive toxicological modeling, high throughput nanomaterial safety testing, human and environmental safety assessment, including emphasis on safe design of nanomaterials;

(iv) The role of air pollutants in asthma, with particular emphasis on the role of oxidative stress in the generation of airway inflammation and asthma.


Additional Information:

Andre Nel is a tenured Professor and practicing allergist/immunologist at UCLA. Dr Nel is Director of the UC Center for the Environmental Impact of Nanotechnology (CEIN), Director of the Center for Nanobiology + Predictive Toxicology, and Co-Director of the UCLA Nanomachine Center.

Dr. Nel obtained his M.B.,Ch.B. degree in Cape Town, South Africa, and subsequently did a post-doctoral fellowship in Immunology at MUSC, which was followed by doctoral thesis on his research.

Dr. Nel is a member of the ASCI, AAAAI, AAI and the Western Association of Physicians. He served as Chair of the Allergy, Immunology, and Transplantation Research Committee, one of the NIAID Study Sections for the review of Training Grants.

Link to my PubMed publications.

Selected Publications:

Barnes Charles S, Alexis Neil E, Bernstein Jonathan A, Cohn John R, Demain Jeffrey G, Horner Elliott, Levetin Estelle, Nel Andre, Phipatanakul Wanda, Climate Change and Our Environment: The Effect on Respiratory and Allergic Disease, The journal of allergy and clinical immunology in practice, 2013, 1 (2), 137-141.
Meng Huan, Mai Wilson X, Zhang Haiyuan, Xue Min, Xia Tian, Lin Sijie, Wang Xiang, Zhao Yang, Ji Zhaoxia, Zink Jeffrey I, Nel Andre E, Codelivery of an optimal drug/siRNA combination using mesoporous silica nanoparticles to overcome drug resistance in breast cancer in vitro and in vivo, ACS nano, 2013, 7 (2), 994-1005.
Liu Rong, Zhang Hai Yuan, Ji Zhao Xia, Rallo Robert, Xia Tian, Chang Chong Hyun, Nel Andre, Cohen Yoram, Development of structure-activity relationship for metal oxide nanoparticles, Nanoscale, 2013, 9 (9-10).
Zhao Yuliang, Nel Andre, Riehemann Kristina, Filling Knowledge Gaps that Distinguish the Safety Profiles of Nano versus Bulk Materials, Small (Weinheim an der Bergstrasse, Germany), 2013, 9 (9-10), 1426-7.
Xia Tian, Malasarn Davin, Lin Sijie, Ji Zhaoxia, Zhang Haiyuan, Miller Robert J, Keller Arturo A, Nisbet Roger M, Harthorn Barbara H, Godwin Hilary A, Lenihan Hunter S, Liu Rong, Gardea-Torresdey Jorge, Cohen Yoram, Mädler Lutz, Holden Patricia A, Zink Jeffrey I, Nel Andre E, Implementation of a Multidisciplinary Approach to Solve Complex Nano EHS Problems by the UC Center for the Environmental Implications of Nanotechnology, Small (Weinheim an der Bergstrasse, Germany), 2013, 9 (9-10), 1428-43.
Bonner James C, Silva Rona M, Taylor Alexia J, Brown Jared M, Hilderbrand Susana C, Castranova Vincent, Porter Dale, Elder Alison, Oberdörster Günter, Harkema Jack R, Bramble Lori A, Kavanagh Terrance J, Botta Dianne, Nel Andre, Pinkerton Kent E, Interlaboratory Evaluation of Rodent Pulmonary Responses to Engineered Nanomaterials: The NIEHS Nano Go Consortium, Environmental health perspectives, 2013, 9 (9-10).
Xia Tian, Hamilton Jr Raymond F, Bonner James C, Crandall Edward D, Elder Alison, Fazlollahi Farnoosh, Girtsman Teri A, Kim Kwang, Mitra Somenath, Ntim Susana A, Orr Galya, Tagmount Mani, Taylor Alexia J, Telesca Donatello, Tolic Ana, Vulpe Christopher D, Walker Andrea J, Wang Xiang, Witzmann Frank A, Wu Nianqiang, Xie Yumei, Zink Jeffrey I, Nel Andre, Holian Andrij, Interlaboratory Evaluation of in Vitro Cytotoxicity and Inflammatory Responses to Engineered Nanomaterials: The NIEHS Nano Go Consortium, Environmental health perspectives, 2013, 9 (9-10).
Li Ning, Wang Meiying, Barajas Berenice, Sioutas Constantinos, Williams Marc A, Nel Andre E, Nrf2 Deficiency in Dendritic Cells Enhances the Adjuvant Effect of Ambient Ultrafine Particles on Allergic Sensitization, Journal of innate immunity, 2013, 9 (9-10).
Li, R., Wang, X., Ji, Zhaoxia., Sun, B., Zhang, H., Chang, C.H., Li, S., Meng, H., Liao, Y.P., Wang, M., Li, Z., Hwang, A.A., Song, T.B., Xu, R., Yang, Y., Zink, J.I., Nel, A.E., Xia, T, Surface Charge and Cellular Processing of Covalently Functionalized Multiwall Carbon Nanotubes Determine Pulmonary Toxicity, ACS nano, 2013, 7 (3), 2352-2368.
Lin Sijie, Zhao Yan, Ji Zhaoxia, Ear Jason, Chang Chong Hyun, Zhang Haiyuan, Low-Kam Cecile, Yamada Kristin, Meng Huan, Wang Xiang, Liu Rong, Pokhrel Suman, Mädler Lutz, Damoiseaux Robert, Xia Tian, Godwin Hilary A, Lin Shuo, Nel Andre E, Zebrafish High-Throughput Screening to Study the Impact of Dissolvable Metal Oxide Nanoparticles on the Hatching Enzyme, ZHE1, Small (Weinheim an der Bergstrasse, Germany), 2013, 9 (9-10), 1776-85.
Lin Sijie, Zhao Yan, Nel Andre E, Lin Shuo, Zebrafish: An In Vivo Model for Nano EHS Studies, Small (Weinheim an der Bergstrasse, Germany), 2013, 9 (9-10), 1608-18.
Liu Rong, Lin Sijie, Rallo Robert, Zhao Yan, Damoiseaux Robert, Xia Tian, Lin Shuo, Nel Andre, Cohen Yoram, Automated phenotype recognition for zebrafish embryo based in vivo high throughput toxicity screening of engineered nano-materials, PloS one, 2012, 7 (4), e35014.
Zamboni William C, Torchilin Vladimir, Patri Anil K, Hrkach Jeff, Stern Stephen, Lee Robert, Nel Andre, Panaro Nicholas J, Grodzinski Piotr, Best practices in cancer nanotechnology: perspective from NCI nanotechnology alliance, Clinical cancer research : an official journal of the American Association for Cancer Research, 2012, 18 (12), 3229-41.
Pokhrel Suman, Nel Andre E, Mädler Lutz, Custom-Designed Nanomaterial Libraries for Testing Metal Oxide Toxicity, Accounts of chemical research, 2012, 6 (12).
Ji, Z., Wang, X., Zhang, H., Lin, S., Meng, H., Sun, B., George, S., Xia, T., Nel, A.E, and Zink, J.I. , Designed Synthesis of CeO2 Nanorods and Nanowires for Studying Toxicological Effects of High Aspect Ratio Nanomaterials, ACS nano, 2012, 6 (6), 5366-5380.
Ji Zhaoxia, Wang Xiang, Zhang Haiyuan, Lin Sijie, Meng Huan, Sun Bingbing, George Saji, Xia Tian, Nel André E, Zink Jeffrey I, Designed synthesis of CeO2 nanorods and nanowires for studying toxicological effects of high aspect ratio nanomaterials, ACS nano, 2012, 6 (6), 5366-80.
Nel Andre, Xia Tian, Meng Huan, Wang Xiang, Lin Sijie, Ji Zhaoxia, Zhang Haiyuan, Nanomaterial Toxicity Testing in the 21st Century: Use of a Predictive Toxicological Approach and High-Throughput Screening, Accounts of chemical research, 2012, 12 (6).
Wang, X., Xia, T., Duch, M.C., Ji, X., Zhang, H., Li, R., Sun, B., Lin, S., Meng, H., Liao,Y., Wang, M., Song, T.,Yang, Y., Hersam, M.C., and Nel, A.E, Pluronic F108 Coating Decreases the Lung Fibrosis Potential of Multiwall Carbon Nanotubes by Reducing Lysosomal Injury, ACS nano, 2012, 12 (6), 3050-3061.
Zhang Haiyuan, Dunphy Darren R, Jiang Xingmao, Meng Huan, Sun Bingbing, Tarn Derrick, Xue Min, Wang Xiang, Lin Sijie, Ji Zhaoxia, Li Ruibin, Garcia Fred L, Yang Jing, Kirk Martin L, Xia Tian, Zink Jeffrey I, Nel Andre, Brinker C Jeffrey, Processing pathway dependence of amorphous silica nanoparticle toxicity: colloidal vs pyrolytic, Journal of the American Chemical Society, 2012, 134 (38), 15790-804.
George Saji, Lin Sijie, Ji Zhaoxia, Thomas Courtney R, Li LinJiang, Mecklenburg Mathew, Meng Huan, Wang Xiang, Zhang Haiyuan, Xia Tian, Hohman J Nathan, Lin Shuo, Zink Jeffrey I, Weiss Paul S, Nel André E, Surface defects on plate-shaped silver nanoparticles contribute to its hazard potential in a fish gill cell line and zebrafish embryos, ACS nano, 2012, 6 (5), 3745-59.
Clemens Daniel L, Lee Bai-Yu, Xue Min, Thomas Courtney R, Meng Huan, Ferris Daniel, Nel Andre E, Zink Jeffrey I, Horwitz Marcus A, Targeted intracellular delivery of antituberculosis drugs to Mycobacterium tuberculosis-infected macrophages via functionalized mesoporous silica nanoparticles, Antimicrobial agents and chemotherapy, 2012, 56 (5), 2535-45.
Gilbert Benjamin, Fakra Sirine C, Xia Tian, Pokhrel Suman, Mädler Lutz, Nel André E, The fate of ZnO nanoparticles administered to human bronchial epithelial cells, ACS nano, 2012, 6 (6), 4921-30.
Zhang Haiyuan, Ji Zhaoxia, Xia Tian, Meng Huan, Low-Kam Cecile, Liu Rong, Pokhrel Suman, Lin Sijie, Wang Xiang, Liao Yu-Pei, Wang Meiying, Li Linjiang, Rallo Robert, Damoiseaux Robert, Telesca Donatello, Madler Lutz, Cohen Yoram, Zink Jeffrey I, Nel Andre E, Use of Metal Oxide Nanoparticle Band Gap To Develop a Predictive Paradigm for Oxidative Stress and Acute Pulmonary Inflammation, ACS nano, 2012, 273 (5).
Bonnell Dawn A, Buriak Jillian M, Chan Warren C W, Hafner Jason H, Hammond Paula T, Hersam Mark C, Javey Ali, Kotov Nicholas A, Nel Andre E, Nordlander Peter J, Penner Reginald M, Rogach Andrey L, Schaak Ray E, Stevens Molly M, Wee Andrew T S, Willson C Grant, Weiss Paul S, We take it personally, ACS nano, 2012, 6 (12), 10417-9.
Liu, R., Rallo, R., George, S., Jia, S., Nair, S., Nel, A.E., and Cohen, Y., Classification nano-SAR modeling for the cytoxicity of a family of metal oxide nanoparticles, Small, 2011, 7 (8), 1118-1126.
Xia Tian, Zhao Yan, Sager Tina, George Saji, Pokhrel Suman, Li Ning, Schoenfeld David, Meng Huan, Lin Sijie, Wang Xiang, Wang Meiying, Ji Zhaoxia, Zink Jeffrey I, Mädler Lutz, Castranova Vincent, Lin Shuo, Nel Andre E, Decreased dissolution of ZnO by iron doping yields nanoparticles with reduced toxicity in the rodent lung and zebrafish embryos, ACS nano, 2011, 5 (2), 1223-35.
Zhang Haiyuan, Xia Tian, Meng Huan, Xue Min, George Saji, Ji Zhaoxia, Wang Xiang, Liu Rong, Wang Meiying, France Bryan, Rallo Robert, Damoiseaux Robert, Cohen Yoram, Bradley Kenneth A, Zink Jeffrey I, Nel Andre E, Differential expression of syndecan-1 mediates cationic nanoparticle toxicity in undifferentiated versus differentiated normal human bronchial epithelial cells, ACS nano, 2011, 5 (4), 2756-69.
Wang Xiang, Xia Tian, Ntim Susana Addo, Ji Zhaoxia, Lin Sijie, Meng Huan, Chung Choong-Heui, George Saji, Zhang Haiyuan, Wang Meiying, Li Ning, Yang Yang, Castranova Vincent, Mitra Somenath, Bonner James C, Nel André E, Dispersal state of multiwalled carbon nanotubes elicits profibrogenic cellular responses that correlate with fibrogenesis biomarkers and fibrosis in the murine lung, ACS nano, 2011, 5 (12), 9772-87.
Li Ning, Nel Andre E, Feasibility of biomarker studies for engineered nanoparticles: what can be learned from air pollution research, Journal of occupational and environmental medicine / American College of Occupational and Environmental Medicine, 2011, 53 (6 Suppl), S74-9.
Lin Sijie, Zhao Yan, Xia Tian, Meng Huan, Ji Zhaoxia, Liu Rong, George Saji, Xiong Sijing, Wang Xiang, Zhang Haiyuan, Pokhrel Suman, Mädler Lutz, Damoiseaux Robert, Lin Shuo, Nel Andre E, High content screening in zebrafish speeds up hazard ranking of transition metal oxide nanoparticles, ACS nano, 2011, 5 (9), 7284-95.
Mirkin, C.A., Nel, A.E., and Thaxton, C.S. Applications, Nanobiosystems, Medicine, and Health, Nanotechnology Research Directions for Societal Needs in 2020, 2011.
Thomas Courtney R, George Saji, Horst Allison M, Ji Zhaoxia, Miller Robert J, Peralta-Videa Jose R, Xia Tian, Pokhrel Suman, Mädler Lutz, Gardea-Torresdey Jorge L, Holden Patricia A, Keller Arturo A, Lenihan Hunter S, Nel Andre E, Zink Jeffrey I, Nanomaterials in the environment: from materials to high-throughput screening to organisms, ACS nano, 2011, 5 (1), 13-20.
George Saji, Pokhrel Suman, Ji Zhaoxia, Henderson Bryana L, Xia Tian, Li LinJiang, Zink Jeffrey I, Nel André E, Mädler Lutz, Role of Fe doping in tuning the band gap of TiO2 for the photo-oxidation-induced cytotoxicity paradigm, Journal of the American Chemical Society, 2011, 133 (29), 11270-8.
Rallo Robert, France Bryan, Liu Rong, Nair Sumitra, George Saji, Damoiseaux Robert, Giralt Francesc, Nel Andre, Bradley Kenneth, Cohen Yoram, Self-organizing map analysis of toxicity-related cell signaling pathways for metal and metal oxide nanoparticles, Environmental science & technology, 2011, 45 (4), 1695-702.
Meng, H., Xue,M., Xia,T., Ji,Z., Tarn,D.Y., Zink, J.I., and Nel, A.E., Use of Size and a Copolymer Design Feature To Improve the Biodistribution and the Enhanced Permeability and Retention Effect of Doxorubicin-Loaded Mesoporous Silica Nanoparticles in a Murine Xenograft Tumor Model, ACS Nano , 2011, 5 (5), 4131-4144.
George Saji, Xia Tian, Rallo Robert, Zhao Yan, Ji Zhaoxia, Lin Sijie, Wang Xiang, Zhang Haiyuan, France Bryan, Schoenfeld David, Damoiseaux Robert, Liu Rong, Lin Shuo, Bradley Kenneth A, Cohen Yoram, Nel André E, Use of a high-throughput screening approach coupled with in vivo zebrafish embryo screening to develop hazard ranking for engineered nanomaterials, ACS nano, 2011, 5 (3), 1805-17.
Meng Huan, Xue Min, Xia Tian, Ji Zhaoxia, Tarn Derrick Y, Zink Jeffrey I, Nel Andre E, Use of size and a copolymer design feature to improve the biodistribution and the enhanced permeability and retention effect of doxorubicin-loaded mesoporous silica nanoparticles in a murine xenograft tumor model, ACS nano, 2011, 5 (5), 4131-44.
Kang Xuedong, Li Ning, Wang Meiying, Boontheung Pinmanee, Sioutas Constantinos, Harkema Jack R, Bramble Lori A, Nel Andre E, Loo Joseph A, Adjuvant effects of ambient particulate matter monitored by proteomics of bronchoalveolar lavage fluid, Proteomics, 2010, 10 (3), 520-31.
Li Ning, Harkema Jack R, Lewandowski Ryan P, Wang Meiying, Bramble Lori A, Gookin Glenn R, Ning Zhi, Kleinman Michael T, Sioutas Constantinos, Nel Andre E, Ambient ultrafine particles provide a strong adjuvant effect in the secondary immune response: implication for traffic-related asthma flares, Am J Physiol Lung Cell Mol Physiol, 2010, 299 (3), L374-83.
Meng Huan, Xue Min, Xia Tian, Zhao Yan-Li, Tamanoi Fuyuhiko, Stoddart J Fraser, Zink Jeffrey I, Nel Andre E, Autonomous in vitro anticancer drug release from mesoporous silica nanoparticles by pH-sensitive nanovalves, Journal of the American Chemical Society, 2010, 132 (36), 12690-7.
Ji Zhaoxia, Jin Xue, George Saji, Xia Tian, Meng Huan, Wang Xiang, Suarez Elizabeth, Zhang Haiyuan, Hoek Eric M V, Godwin Hilary, Nel Andre E, Zink Jeffrey I, Dispersion and stability optimization of TiO2 nanoparticles in cell culture media, Environ Sci Technol, 2010, 44 (19), 7309-14.
Meng Huan, Liong Monty, Xia Tian, Li Zongxi, Ji Zhaoxia, Zink Jeffrey I, Nel Andre E, Engineered design of mesoporous silica nanoparticles to deliver doxorubicin and P-glycoprotein siRNA to overcome drug resistance in a cancer cell line, ACS Nano, 2010, 4 (8), 4539-50.
Wang Xiang, Xia Tian, Ntim Susana Addo, Ji Zhaoxia, George Saji, Meng Huan, Zhang Haiyuan, Castranova Vincent, Mitra Somenath, Nel André E, Quantitative techniques for assessing and controlling the dispersion and biological effects of multiwalled carbon nanotubes in mammalian tissue culture cells, ACS nano, 2010, 4 (12), 7241-52.
George Saji, Pokhrel Suman, Xia Tian, Gilbert Benjamin, Ji Zhaoxia, Schowalter Marco, Rosenauer Andreas, Damoiseaux Robert, Bradley Kenneth A, Mädler Lutz, Nel Andre E, Use of a rapid cytotoxicity screening approach to engineer a safer zinc oxide nanoparticle through iron doping, ACS nano, 2010, 4 (1), 15-29.
Meng Huan, Xia Tian, George Saji, Nel Andre E, A predictive toxicological paradigm for the safety assessment of nanomaterials, ACS nano, 2009, 3 (7), 1620-7.
Kovochich Michael, Espinasse Benjamin, Auffan Melanie, Hotze Ernest M, Wessel Lauren, Xia Tian, Nel Andre E, Wiesner Mark R, Comparative toxicity of C60 aggregates toward mammalian cells: role of tetrahydrofuran (THF) decomposition, Environmental science & technology, 2009, 43 (16), 6378-84.
Klichko Yaroslav, Liong Monty, Choi Eunshil, Angelos Sarah, Nel Andre E, Stoddart J Fraser, Tamanoi Fuyuhiko, Zink Jeffrey I, Mesostructured Silica for Optical Functionality, Nanomachines, and Drug Delivery, Journal of the American Ceramic Society. American Ceramic Society, 2009, 92 (s1), s2-s10.
Zhang Lifeng, Wang Meiying, Kang Xuedong, Boontheung Pinmanee, Li Ning, Nel Andre E, Loo Joseph A, Oxidative stress and asthma: proteome analysis of chitinase-like proteins and FIZZ1 in lung tissue and bronchoalveolar lavage fluid, Journal of proteome research, 2009, 8 (4), 1631-8.
Araujo Jesus A, Nel Andre E, Particulate matter and atherosclerosis: role of particle size, composition and oxidative stress, Particle and fibre toxicology, 2009, 6 (10), 24.
Xia Tian, Kovochich Michael, Liong Monty, Meng Huan, Kabehie Sanaz, George Saji, Zink Jeffrey I, Nel Andre E, Polyethyleneimine coating enhances the cellular uptake of mesoporous silica nanoparticles and allows safe delivery of siRNA and DNA constructs, ACS nano, 2009, 3 (10), 3273-86.
Xia Tian, Li Ning, Nel Andre E, Potential health impact of nanoparticles, Annual review of public health, 2009, 30 (4), 137-50.
Ning Li, Meiying Wang, Lori A. Bramble, Debra A. Schmitz, James J. Schauer, Constantinos Sioutas, Jack R. Harkema, Andre E. Nel, The Adjuvant Effect of Ambient Particulate Matter Is Closely Reflected by the Particulate Oxidant Potential, Environ Health Perspect, 2009, 117 (7), 1116-23 .
Godwin Hilary A, Chopra Kabir, Bradley Kenneth A, Cohen Yoram, Harthorn Barbara Herr, Hoek Eric M V, Holden Patricia, Keller Arturo A, Lenihan Hunter S, Nisbet Roger M, Nel Andre E, The University of California Center for the Environmental Implications of Nanotechnology, Environ Sci Technol, 2009, 43 (17), 6453-7.
Li Ning, Wang Meiying, Bramble Lori A, Schmitz Debra A, Schauer James J, Sioutas Constantinos, Harkema Jack R, Nel Andre E, The adjuvant effect of ambient particulate matter is closely reflected by the particulate oxidant potential, Environ Health Perspect, 2009, 117 (7), 1116-23.
Viera Loida, Chen Karin, Nel Andre, Lloret Maria Garcia, The impact of air pollutants as an adjuvant for allergic sensitization and asthma, Current allergy and asthma reports, 2009, 9 (4), 327-33.
Nel Andre E, Mädler Lutz, Velegol Darrell, Xia Tian, Hoek Eric M V, Somasundaran Ponisseril, Klaessig Fred, Castranova Vince, Thompson Mike, Understanding biophysicochemical interactions at the nano-bio interface, Nature materials, 2009, 8 (7), 543-57.
Araujo Jesus A, Barajas Berenice, Kleinman Michael, Wang Xuping, Bennett Brian J, Gong Ke Wei, Navab Mohamad, Harkema Jack, Sioutas Constantinos, Lusis Aldons J, Nel Andre E, Ambient particulate pollutants in the ultrafine range promote early atherosclerosis and systemic oxidative stress, Circulation research, 2008, 102 (5), 589-96.
Xia Tian, Kovochich Michael, Liong Monty, Zink Jeffrey I, Nel Andre E, Cationic polystyrene nanosphere toxicity depends on cell-specific endocytic and mitochondrial injury pathways, ACS nano, 2008, 2 (1), 85-96.
Xia Tian, Kovochich Michael, Liong Monty, Mädler Lutz, Gilbert Benjamin, Shi Haibin, Yeh Joanne I, Zink Jeffrey I, Nel Andre E, Comparison of the mechanism of toxicity of zinc oxide and cerium oxide nanoparticles based on dissolution and oxidative stress properties, ACS nano, 2008, 2 (10), 2121-34.
Ayres Jon G, Borm Paul, Cassee Flemming R, Castranova Vincent, Donaldson Ken, Ghio Andy, Harrison Roy M, Hider Robert, Kelly Frank, Kooter Ingeborg M, Marano Francelyne, Maynard Robert L, Mudway Ian, Nel Andre, Sioutas Constantinos, Smith Steve, Baeza-Squiban Armelle, Cho Art, Duggan Sean, Froines John, Evaluating the toxicity of airborne particulate matter and nanoparticles by measuring oxidative stress potential--a workshop report and consensus statement, Inhalation toxicology, 2008, 20 (1), 75-99.
Riedl Marc A, Nel Andre E, Importance of oxidative stress in the pathogenesis and treatment of asthma, Current opinion in allergy and clinical immunology, 2008, 8 (1), 49-56.
Schröder Nicolas W J, Crother Timothy R, Naiki Yoshikazu, Chen Shuang, Wong Michelle H, Yilmaz Atilla, Slepenkin Anatoly, Schulte Danica, Alsabeh Randa, Doherty Terence M, Peterson Ellena, Nel Andre E, Arditi Moshe, Innate immune responses during respiratory tract infection with a bacterial pathogen induce allergic airway sensitization, The Journal of allergy and clinical immunology, 2008, 122 (3), 595-602.e5.
Liong Monty, Lu Jie, Kovochich Michael, Xia Tian, Ruehm Stefan G, Nel Andre E, Tamanoi Fuyuhiko, Zink Jeffrey I, Multifunctional inorganic nanoparticles for imaging, targeting, and drug delivery, ACS nano, 2008, 2 (5), 889-96.
Xia Tian, Rome Leonard, Nel Andre, Nanobiology: particles slip cell security, Nature materials, 2008, 7 (7), 519-20.
Kim Hyon-Jeen, Barajas Berenice, Wang Meiying, Nel Andre E, Nrf2 activation by sulforaphane restores the age-related decrease of T(H)1 immunity: role of dendritic cells, The Journal of allergy and clinical immunology, 2008, 121 (5), 1255-1261.e7.
Chatila Talal A, Li Ning, Garcia-Lloret Maria, Kim Hyon-Jeen, Nel Andre E, T-cell effector pathways in allergic diseases: transcriptional mechanisms and therapeutic targets, The Journal of allergy and clinical immunology, 2008, 121 (4), 812-23; quiz 824-5.
Bernstein Jonathan A, Alexis Neil, Bacchus Hyacinth, Bernstein I Leonard, Fritz Pat, Horner Elliot, Li Ning, Mason Stephany, Nel Andre, Oullette John, Reijula Kari, Reponen Tina, Seltzer James, Smith Alisa, Tarlo Susan M, The health effects of non-industrial indoor air pollution, The Journal of allergy and clinical immunology, 2008, 121 (3), 585-91.
Li Ning, Xia Tian, Nel Andre E, The role of oxidative stress in ambient particulate matter-induced lung diseases and its implications in the toxicity of engineered nanoparticles, Free radical biology & medicine, 2008, 44 (9), 1689-99.
Gong Ke Wei, Zhao Wei, Li Ning, Barajas Berenice, Kleinman Michael, Sioutas Constantinos, Horvath Steve, Lusis Aldons J, Nel Andre, Araujo Jesus A, Air-pollutant chemicals and oxidized lipids exhibit genome-wide synergistic effects on endothelial cells, Genome biology, 2007, 8 (7), R149.
Kim Hyon-Jeen, Barajas Berenice, Chan Ray Chun-Fai, Nel Andre E, Glutathione depletion inhibits dendritic cell maturation and delayed-type hypersensitivity: implications for systemic disease and immunosenescence, The Journal of allergy and clinical immunology, 2007, 119 (5), 1225-33.
Xia Tian, Kovochich Michael, Nel Andre E, Impairment of mitochondrial function by particulate matter (PM) and their toxic components: implications for PM-induced cardiovascular and lung disease, Frontiers in bioscience : a journal and virtual library, 2007, 12 (2), 1238-46.
Lu Jie, Liong Monty, Sherman Sean, Xia Tian, Kovochich Michael, Nel Andre E, Zink Jeffrey I, Tamanoi Fuyuhiko, Mesoporous Silica Nanoparticles for Cancer Therapy: Energy-Dependent Cellular Uptake and Delivery of Paclitaxel to Cancer Cells, Nanobiotechnology : the journal at the intersection of nanotechnology, molecular biology, and biomedical sciences, 2007, 3 (2), 89-95.
Shi Haibin, Xia Tian, Nel Andre E, Yeh Joanne I, Part II: coordinated biosensors--development of enhanced nanobiosensors for biological and medical applications, Nanomedicine (London, England), 2007, 2 (5), 599-614.
Jung EunMi Juliana, Avliyakulov Nuraly K, Boontheung Pinmanee, Loo Joseph A, Nel Andre E, Pro-oxidative DEP chemicals induce heat shock proteins and an unfolding protein response in a bronchial epithelial cell line as determined by DIGE analysis, Proteomics, 2007, 7 (21), 3906-18.
Xia Tian, Kovochich Michael, Brant Jonathan, Hotze Matt, Sempf Joan, Oberley Terry, Sioutas Constantinos, Yeh Joanne I, Wiesner Mark R, Nel Andre E, Comparison of the abilities of ambient and manufactured nanoparticles to induce cellular toxicity according to an oxidative stress paradigm, Nano letters, 2006, 6 (8), 1794-807.
Gilmour M Ian, Jaakkola Maritta S, London Stephanie J, Nel Andre E, Rogers Christine A, How exposure to environmental tobacco smoke, outdoor air pollutants, and increased pollen burdens influences the incidence of asthma, Environmental health perspectives, 2006, 114 (4), 627-33.
Chan Ray Chun-Fai, Wang Meiying, Li Ning, Yanagawa Yoshiki, Onoé Kazunori, Lee James J, Nel Andre E, Pro-oxidative diesel exhaust particle chemicals inhibit LPS-induced dendritic cell responses involved in T-helper differentiation, The Journal of allergy and clinical immunology, 2006, 118 (2), 455-65.
Li Ning, Nel Andre E, Role of the Nrf2-mediated signaling pathway as a negative regulator of inflammation: implications for the impact of particulate pollutants on asthma, Antioxidants & redox signaling, 2006, 8 (1-2), 88-98.
Xia Tian, Kovochich Michael, Nel Andre, The role of reactive oxygen species and oxidative stress in mediating particulate matter injury, Clinics in occupational and environmental medicine, 2006, 5 (4), 817-36.
Nel Andre, Xia Tian, Mädler Lutz, Li Ning, Toxic potential of materials at the nanolevel, Science (New York, N.Y.), 2006, 311 (5761), 622-7.
Phalen Robert F, Oldham Michael J, Nel Andre E, Tracheobronchial particle dose considerations for in vitro toxicology studies, Toxicological sciences : an official journal of the Society of Toxicology, 2006, 92 (1), 126-32.
Nel A , Air Pollution-Related Illness: Biomolecular Effects of Particles, Science, 2005, 308 (5273), 804-6.
Xiao GG, Nel AE, Loo JA, Nitrotyrosine-modified proteins and oxidative stress induced by diesel exhaust particles, Electrophoresis, 2005, 26 (1), 280-92.
Wang M, Xiao GC, Li N, Xie Y, Loo JA and Nel AE, Phosphorproteome and cytokine array analysis show MAP kinases mediate inflammation by pro-oxidative diesel exhaust particle chemicals, Electrophoresis, 2005, 26 (11), 2092-2108.
Kim HJ, Nel AE, The role of phase II antioxidant enzymes in protecting memory T cells from spontaneous apoptosis in young and old mice, Journal of Immunology, 2005, 175 (5), 2948-59.
Li N, Alam J, Venkatesan MI, Eiguren-Fernandez A, Schmitz D, Di Stefano E, Slaughter N, Killeen E, Wang X, Huang A, Wang M, Miguel AH, Cho A, Sioutas C, Nel AE, Nrf2 is a key transcription factor that regulates antioxidant defense in macrophages and epithelial cells: protecting against the proinflammatory and oxidizing effects of diesel exhaust chemicals, Journal of Immunology, 2004, 173 (5), 3467-81.
Xia T, Korge P, Weiss JN, Li N, Venkatesen I, Sioutas C and Nel A, Quinones and Aromatic Chemical Compounds in Particulate Matter (PM) Induce Mitochondrial Dysfunction: Implications for PM-induced Oxidative Stress and Toxicity, Environ Health Perspectives, 2004, 112 (14), 1347-1358.
Li N, Hao M, Phalen RF, Hinds WC, Nel AE, Particulate air pollutants and asthma. A paradigm for the role of oxidative stress in PM-induced adverse health effects, Clinical Immunology, 2003, 109 (3), 250-65.
Xiao GG, Wang M, Li N, Loo JA, Nel AE, Use of proteomics to demonstrate a hierarchical oxidative stress response to diesel exhaust particle chemicals in a macrophage cell line, The Journal of Biological Chemistry, 2003, 278 (50), 50781-90.
Yuan J, Bae D, Cantrell D, Nel AE, Rozengurt E., Protein kinase D is a downstream target of protein kinase Ctheta, Biochem Biophys Res Commun, 2002, 291 (3), 444-52.
Nel AE, T-cell activation through the antigen receptor. Part 1: signaling components, signaling pathways, and signal integration at the T-cell antigen receptor synapse, J Allergy Clin Immunol. , 2002, 109 (5), 758-70.
Whitekus MJ, Li N, Zhang M, Wang M, Horwitz MA, Nelson SK, Horwitz LD, Brechun N, Diaz-Sanchez D, Nel AE, Thiol antioxidants inhibit the adjuvant effects of aerosolized diesel exhaust particles in a murine model for ovalbumin sensitization, J Immunol, 2002, 168 (5), 2560-7.